A tale of two endothelins: the rise and fall of the corpus luteum
Magdalena Szymanska A B , Raghavendra Basavaraja A C and Rina Meidan
A *
A
B Present address:
C Present address:
Abstract
Endothelins are small 21 amino acid peptides that interact with G-protein-coupled receptors. They are highly conserved across species and play important roles in vascular biology as well as in disease development and progression. Endothelins, mainly endothelin-1 and endothelin-2, are intricately involved in ovarian function and metabolism. These two peptides differ only in two amino acids but are encoded by different genes, which suggests an independent regulation and a cell-specific mode of expression. This review aims to comprehensively discuss the distinct regulation and roles of endothelin-1 and endothelin-2 regarding corpus luteum function throughout its life span.
Keywords: corpus luteum, endothelin-1, endothelin-2, hypoxia, interferon tau, PCOS, prostaglandin F2 alpha, sirtuin 1.
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