Fifty years of reproductive biology in Australia: highlights from the 50th Annual Meeting of the Society for Reproductive Biology (SRB)
Elizabeth G. Bromfield A , Samson N. Dowland B , Jessica E. M. Dunleavy C , Kylie R. Dunning
D E , Olivia J. Holland F , Brendan J. Houston C , Michael W. Pankhurst G , Dulama Richani H , Angelique H. Riepsamen H , Ryan Rose E I and Michael J. Bertoldo H J K
+ Author Affiliations
- Author Affiliations
A Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, The University of Newcastle, NSW 2308, Australia.
B School of Medical Sciences (Discipline of Anatomy and Histology) and The Bosch Institute, F13 Anderson Stuart Building, The University of Sydney, Sydney, NSW 2006, Australia.
C School of Biological Sciences, Monash University, Clayton, Vic. 3168, Australia.
D Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, University of Adelaide, SA 5005, Australia.
E Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
F School of Medical Science, Griffith University, Gold Coast Campus, Southport, Qld 5005, Australia.
G Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
H Fertility and Research Centre, School of Women’s and Children’s Health, UNSW, Randwick 2052, NSW 4222, Australia.
I Fertility SA, St. Andrews Hospital, South Terrace, Adelaide, SA 5000, Australia.
J School of Medical Sciences, UNSW, Randwick, NSW 2052, Australia.
K Corresponding author. Email: michael.bertoldo@unsw.edu.au
Reproduction, Fertility and Development 31(5) 829-836 https://doi.org/10.1071/RD18436
Submitted: 29 October 2018 Accepted: 3 December 2018 Published: 14 January 2019
Abstract
The 2018 edition of the Society for Reproductive Biology’s (SRB) Annual Meeting was a celebration of 50 years of Australian research into reproductive biology. The past 50 years has seen many important contributions to this field, and these advances have led to changes in practice and policy, improvements in the efficiency of animal reproduction and improved health outcomes. This conference review delivers a dedicated summary of the symposia, discussing emerging concepts, raising new questions and proposing directions forward. Notably, the symposia discussed in this review emphasised the impact that reproductive research can have on quality of life and the health trajectories of individuals. The breadth of the research discussed encompasses the central regulation of fertility and cyclicity, life course health and how the environment of gametes and embryos can affect subsequent generations, significant advances in our understanding of placental biology and pregnancy disorders and the implications of assisted reproductive technologies on population health. The importance of a reliable food supply and protection of endangered species is also discussed. The research covered at SRB’s 2018 meeting not only recognised the important contributions of its members over the past 50 years, but also highlighted key findings and avenues for innovation moving forward that will enable the SRB to continue making significant contributions for the next 50 years.
Additional keywords: assisted reproduction, fetal programming, fertility, gamete, gestation, implantation, placenta, preterm birth.
References
Aitken, R. J., and Krausz, C. (2001). Oxidative stress, DNA damage and the Y chromosome. Reproduction 122, 497–506.| Oxidative stress, DNA damage and the Y chromosome.Crossref | GoogleScholarGoogle Scholar | 11570956PubMed |
Akison, L. K., Kuo, J., Reid, N., Boyd, R. N., and Moritz, K. M. (2018). Effect of choline supplementation on neurological, cognitive, and behavioral outcomes in offspring arising from alcohol exposure during development: a quantitative systematic review of clinical and preclinical studies. Alcohol. Clin. Exp. Res. 42, 1591–1611.
| Effect of choline supplementation on neurological, cognitive, and behavioral outcomes in offspring arising from alcohol exposure during development: a quantitative systematic review of clinical and preclinical studies.Crossref | GoogleScholarGoogle Scholar | 29928762PubMed |
Armstrong, D. T., Kotaras, P. J., and Earl, C. R. (1997). Advances in production of embryos in vitro from juvenile and prepubertal oocytes from the calf and lamb. Reprod. Fertil. Dev. 9, 333–339.
| Advances in production of embryos in vitro from juvenile and prepubertal oocytes from the calf and lamb.Crossref | GoogleScholarGoogle Scholar | 9261881PubMed |
Bertoldo, M. J., Andraweera, P. H., Bromfield, E. G., Cousins, F. L., Lindsay, L. A., Paiva, P., Regan, S. L., Rose, R. D., and Akison, L. K. (2018). Recent and emerging reproductive biology research in Australia and New Zealand: highlights from the Society for Reproductive Biology Annual Meeting, 2017. Reprod. Fertil. Dev. 30, 1049–1054.
| Recent and emerging reproductive biology research in Australia and New Zealand: highlights from the Society for Reproductive Biology Annual Meeting, 2017.Crossref | GoogleScholarGoogle Scholar |
Biggers, J. D. (2012). IVF and embryo transfer: historical origin and development. Reprod. Biomed. Online 25, 118–127.
| IVF and embryo transfer: historical origin and development.Crossref | GoogleScholarGoogle Scholar | 22695311PubMed |
Billington, W. D. (2003). The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar. J. Reprod. Immunol. 60, 1–11.
| The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar.Crossref | GoogleScholarGoogle Scholar | 14568673PubMed |
Catt, S. L., Catt, J. W., Gomez, M. C., Maxwell, W. M. C., and Evans, G. (1996). Birth of a male lamb derived from an in vitro matured oocyte fertilised by intracytoplasmic injection of a single presumptive male sperm. Vet. Rec. 139, 494–495.
| Birth of a male lamb derived from an in vitro matured oocyte fertilised by intracytoplasmic injection of a single presumptive male sperm.Crossref | GoogleScholarGoogle Scholar | 8950820PubMed |
Chang, M. C. (1959). Fertilization of rabbit ova in vitro. Nature 184, 466–467.
| Fertilization of rabbit ova in vitro.Crossref | GoogleScholarGoogle Scholar | 13809155PubMed |
Cheong, J. N., Wlodek, M. E., Moritz, K. M., and Cuffe, J. S. (2016). Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations. J. Physiol. 594, 4727–4740.
| Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations.Crossref | GoogleScholarGoogle Scholar | 26970222PubMed |
Clarke, I. J., and Cummins, J. T. (1982). The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111, 1737–1739.
| The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes.Crossref | GoogleScholarGoogle Scholar | 6751801PubMed |
Clarke, I. J., Cummins, J. T., and de Kretzer, D. (1983). Pituitary gland function after disconnection from direct hypothalamic influences in the sheep. Neuroendocrinology 36, 376–384.
| Pituitary gland function after disconnection from direct hypothalamic influences in the sheep.Crossref | GoogleScholarGoogle Scholar | 6406927PubMed |
De Kretzer, D., Dennis, B., Leeton, J., Lopata, A., Outch, K., Talbot, J., and Wood, C. (1973). Transfer of a human zygote. Lancet 302, 728–729.
| Transfer of a human zygote.Crossref | GoogleScholarGoogle Scholar |
Delforce, S. J., Wang, Y., Van-Aalast, M. E., Corbisier de Meaultsart, C., Morris, B. J., Broughton-Pipkin, F., Roberts, C. T., Lumbers, E. R., and Pringle, K. G. (2016). Effect of oxygen on the expression of renin–angiotensin system components in a human trophoblast cell line. Placenta 37, 1–6.
| Effect of oxygen on the expression of renin–angiotensin system components in a human trophoblast cell line.Crossref | GoogleScholarGoogle Scholar | 26748156PubMed |
Dickinson, H., Moss, T. J., Gatford, K. L., Moritz, K. M., Akison, L. K., Fullston, T., Hryciw, D. H., Maloney, C. A., Morris, M. J., Wooldridge, A. L., Schjenjen, J. E., Roberston, S. A., Waddell, B. J., Mark, P. J., Wyrwoll, C. S., Ellery, S. J., Thornburg, K. L., Muhlhausler, B. S., and Morrison, J. L. (2016). A review of fundamental principles for animal models of DOHaD research: an Australian perspective. J. Dev. Orig. Health Dis. 7, 449–472.
| A review of fundamental principles for animal models of DOHaD research: an Australian perspective.Crossref | GoogleScholarGoogle Scholar | 27689313PubMed |
Evans, J., Infusini, G., McGovern, J., Cuttle, L., Webb, A., Nebl, T., Milla, L., Kimble, R., Kempf, M., Andrews, C. J., Leavesley, D., and Salamonsen, L. A. (2018). Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair. FASEB J , .
| Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair.Crossref | GoogleScholarGoogle Scholar | 30036086PubMed |
Gardner, D. K., Lane, M., Spitzer, A., and Batt, P. A. (1994). Enhanced rates of cleavage and development for sheep zygotes cultured to the blastocyst stage in vitro in the absence of serum and somatic cells: amino acids, vitamins, and culturing embryos in groups stimulate development. Biol. Reprod. 50, 390–400.
| Enhanced rates of cleavage and development for sheep zygotes cultured to the blastocyst stage in vitro in the absence of serum and somatic cells: amino acids, vitamins, and culturing embryos in groups stimulate development.Crossref | GoogleScholarGoogle Scholar | 8142556PubMed |
Giorgione, V., Parazzini, F., Fesslova, V., Cipriani, S., Candiani, M., Inversetti, A., Sigismondi, C., Tiberio, F., and Cavoretto, P. (2018). Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta-analysis. Ultrasound Obstet. Gynecol. 51, 33–42.
| Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta-analysis.Crossref | GoogleScholarGoogle Scholar | 29164811PubMed |
Goding, J. R., Catt, K. J., Brown, J. M., Kaltenbach, C. C., Cumming, I. A., and Mole, B. J. (1969). Radioimmunoassay for ovine luteinizing hormone. Secretion of luteinizing hormone during estrus and following estrogen administration in sheep. Endocrinology 85, 133–142.
| Radioimmunoassay for ovine luteinizing hormone. Secretion of luteinizing hormone during estrus and following estrogen administration in sheep.Crossref | GoogleScholarGoogle Scholar | 5815012PubMed |
Guerin, L. R., Prins, J. R., and Roberston, S. A. (2009). Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum. Reprod. Update 15, 517–535.
| Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?Crossref | GoogleScholarGoogle Scholar | 19279047PubMed |
Handelsman, D. J., Jimenez, M., Singh, G. K., Spaliviero, J., Deasi, R., and Walters, K. A. (2015). Measurement of testosterone by immunoassays and mass spectrometry in mouse serum, testicular, and ovarian extracts. Endocrinology 156, 400–405.
| Measurement of testosterone by immunoassays and mass spectrometry in mouse serum, testicular, and ovarian extracts.Crossref | GoogleScholarGoogle Scholar | 25365769PubMed |
Hetz, J. A., Menzies, B. R., Shaw, G., Stefanidis, A., Cowley, M. A., and Renfree, M. B. (2016). Effects of nutritional manipulation on body composition in the developing marsupial, Macropus eugenii. Mol. Cell. Endocrinol. 428, 148–160.
| Effects of nutritional manipulation on body composition in the developing marsupial, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 27032712PubMed |
Hogg, K., and Western, P. S. (2015). Refurbishing the germline epigenome: out with the old, in with the new. Semin. Cell Dev. Biol. 45, 104–113.
| Refurbishing the germline epigenome: out with the old, in with the new.Crossref | GoogleScholarGoogle Scholar | 26597001PubMed |
Hummitzsch, K., Irving-Rodgers, H. F., Hatzirodos, N., Bonner, W., Sabatier, L., Reinhardt, D. P., Sado, Y., Ninomiya, Y., Wilheim, D., and Rodgers, R. J. (2013). A new model of development of the mammalian ovary and follicles PLoS One 8, e55578.
| A new model of development of the mammalian ovary and folliclesCrossref | GoogleScholarGoogle Scholar | 23409002PubMed |
Kalisch-Smith, J. I., and Moritz, K. M. (2018). Detrimental effects of alcohol exposure around conception: putative mechanisms. Biochem. Cell Biol. 96, 107–116.
| Detrimental effects of alcohol exposure around conception: putative mechanisms.Crossref | GoogleScholarGoogle Scholar | 29112458PubMed |
Khourdaji, I., Zillioux, J., Eisenfrats, K., Foley, D., and Smith, R. (2018). The future of male contraception: a fertile ground. Transl. Androl. Urol. 7, S220–S235.
| The future of male contraception: a fertile ground.Crossref | GoogleScholarGoogle Scholar | 29928620PubMed |
Lane, M., Zander-Fox, D. L., Robker, R. L., and McPherson, N. O. (2015). Peri-conception parental obesity, reproductive health, and transgenerational impacts. Trends Endocrinol. Metab. 26, 84–90.
| Peri-conception parental obesity, reproductive health, and transgenerational impacts.Crossref | GoogleScholarGoogle Scholar | 25523615PubMed |
Lindsay, L. A., Dowland, S. N., and Murphy, C. R. (2016). Uterine focal adhesions are retained at implantation after rat ovarian hyperstimulation. Reproduction 152, 753–763.
| Uterine focal adhesions are retained at implantation after rat ovarian hyperstimulation.Crossref | GoogleScholarGoogle Scholar | 27651522PubMed |
Maldini, C. R., Ellis, G. I., and Riley, J. L. (2018). CAR T cells for infection, autoimmunity and allotransplantation. Nat. Rev. Immunol. 18, 605–616.
| CAR T cells for infection, autoimmunity and allotransplantation.Crossref | GoogleScholarGoogle Scholar | 30046149PubMed |
Martin, G. B., Oldham, C. M., and Lindsay, D. R. (1980). Increased plasma LH levels in seasonally anovular merino ewes following the introduction of rams. Anim. Reprod. Sci. 3, 125–132.
| Increased plasma LH levels in seasonally anovular merino ewes following the introduction of rams.Crossref | GoogleScholarGoogle Scholar |
Martin, G. B., Rodger, J., and Blache, D. (2004). Nutritional and environmental effects on reproduction in small ruminants. Reprod. Fertil. Dev. 16, 491–501.
| Nutritional and environmental effects on reproduction in small ruminants.Crossref | GoogleScholarGoogle Scholar | 15315748PubMed |
McPherson, N. O., Bell, V. G., Zander-Fox, D. L., Fullston, T., Wu, L. L., Robker, R. L., and Lane, M. (2015). When two obese parents are worse than one! Impacts on embryo and fetal development. Am. J. Physiol. Endocrinol. Metab. 309, E568–E581.
| When two obese parents are worse than one! Impacts on embryo and fetal development.Crossref | GoogleScholarGoogle Scholar | 26199280PubMed |
Nguyen, Q. N., Zerafa, N., Liew, S. H., Morgan, F. H., Strasser, A., Scott, C. L., Findlay, J. K., Hickey, M., and Hutt, K. J. (2018). Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility. Cell Death Dis. 9, 618.
| Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.Crossref | GoogleScholarGoogle Scholar | 29795269PubMed |
Onda, K., Tong, S., Beard, S., Binder, N., Muto, M., Senadheera, S. N., Parry, L., Dilworth, M., Renshall, L., Brownfoot, F., Hastie, R., Tuohey, L., Palmer, K., Hirano, T., Ikawa, M., Kaitu’u-Lino, T., and Hannan, N. J. (2017). Proton pump inhibitors decrease soluble fms-like tyrosine kinase-1 and soluble endoglin secretion, decrease hypertension, and rescue endothelial dysfunction. Hypertension 69, 457–468.
| Proton pump inhibitors decrease soluble fms-like tyrosine kinase-1 and soluble endoglin secretion, decrease hypertension, and rescue endothelial dysfunction.Crossref | GoogleScholarGoogle Scholar | 28115513PubMed |
Patton, G. C., Olsson, C. A., Skirbekk, V., Saffery, R., Wlodek, M. E., Azzopardi, P. S., Stonawski, M., Rasmussen, B., Spry, E., Francis, K., Bhutta, Z. A., Kassebaum, N. J., Mokdad, A. H., Murray, C. J. L., Prentice, A. M., Reavley, N., Sheehan, P., Sweeny, K., Viner, R. M., and Sawyer, S. M. (2018). Adolescence and the next generation. Nature 554, 458–466.
| Adolescence and the next generation.Crossref | GoogleScholarGoogle Scholar | 29469095PubMed |
Pringle, K. G., Kind, K. L., Sferruzzi, A. N., Thompson, J. G., and Roberts, C. T. (2010). Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy. Hum. Reprod. Update 16, 415–431.
| Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy.Crossref | GoogleScholarGoogle Scholar | 19926662PubMed |
Prokopuk, L., Stringer, J. M., Hogg, K., Elgass, K. D., and Western, P. S. (2017). PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells. Epigenetics Chromatin 10, 7.
| PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells.Crossref | GoogleScholarGoogle Scholar | 28239420PubMed |
Prokopuk, L., Hogg, K., and Western, P. S. (2018a). Pharmacological inhibition of EZH2 disrupts the female germline epigenome. Clin. Epigenetics 10, 33.
| Pharmacological inhibition of EZH2 disrupts the female germline epigenome.Crossref | GoogleScholarGoogle Scholar | 29515677PubMed |
Prokopuk, L., Stringer, J. M., White, C. R., Vossen, R. H. A. M., White, S. J., Cohen, A. S. A., Gibson, W. T., and Western, P. S. (2018b). Loss of maternal EED results in postnatal overgrowth. Clin. Epigenetics 10, 95.
| Loss of maternal EED results in postnatal overgrowth.Crossref | GoogleScholarGoogle Scholar | 30005706PubMed |
Roberts, C. T. (2010). IFPA Award in Placentology Lecture: complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health. Placenta 31, S47–S53.
| IFPA Award in Placentology Lecture: complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health.Crossref | GoogleScholarGoogle Scholar | 20096927PubMed |
Robertson, D. M., de Vos, F. L., Foulds, L. M., McLachlan, R. I., Burger, H. G., Morgan, F. J., Hearn, M. T., and de Kretzer, D. (1986). Isolation of a 31 kDa form of inhibin from bovine follicular fluid. Mol. Cell. Endocrinol. 44, 271–277.
| Isolation of a 31 kDa form of inhibin from bovine follicular fluid.Crossref | GoogleScholarGoogle Scholar | 3082696PubMed |
Robertson, S. A., Prins, J. R., Sharkey, D. J., and Moldenhauer, L. M. (2013). Seminal fluid and the generation of regulatory T cells for embryo implantation. Am. J. Reprod. Immunol. 69, 315–330.
| Seminal fluid and the generation of regulatory T cells for embryo implantation.Crossref | GoogleScholarGoogle Scholar | 23480148PubMed |
Robker, R. L., Hennebold, J. D., and Russell, D. L. (2018). Coordination of ovulation and oocyte maturation: a good egg at the right time. Endocrinology 159, 3209–3218.
| Coordination of ovulation and oocyte maturation: a good egg at the right time.Crossref | GoogleScholarGoogle Scholar | 30010832PubMed |
Rolnik, D. L., Wright, D., Poon, L. C., O’Gorman, N., Syngelaki, A., de Paco Matallana, C., Akolekar, R., Cicero, S., Janga, D., Singh, M., Molina, F. S., Persico, N., Jani, J. C., Plasencia, W., Papaioannou, G., Tenenbaum-Gavish, K., Meiri, H., Gizurarson, S., Maclagan, K., and Nicolaides, K. H. (2017). Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N. Engl. J. Med. 377, 613–622.
| Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia.Crossref | GoogleScholarGoogle Scholar | 28657417PubMed |
Smith, G. C. S. (2018). The STRIDER trial: one step forward, one step back. Lancet Child Adolesc. Health 2, 80–81.
| The STRIDER trial: one step forward, one step back.Crossref | GoogleScholarGoogle Scholar |
Tervit, H. R., Whittingham, D. G., and Rowson, L. E. A. (1972). Succesful culture in vitro of sheep and cattle ova. J. Reprod. Fertil. 30, 493–497.
| Succesful culture in vitro of sheep and cattle ova.Crossref | GoogleScholarGoogle Scholar | 4672493PubMed |
Trott, J. F., Simpson, K. J., Moyle, R. L., Hearn, C. M., Shaw, G., Nicholas, K. R., and Renfree, M. B. (2003). Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii). Biol. Reprod. 68, 929–936.
| Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii).Crossref | GoogleScholarGoogle Scholar | 12604644PubMed |
Trounson, A., and Mohr, L. (1983). Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature 305, 707–709.
| Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo.Crossref | GoogleScholarGoogle Scholar | 6633637PubMed |
Trounson, A. O., Leeton, J. F., Wood, C., Webb, J., and Wood, J. (1981). Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle. Science 212, 681–682.
| Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle.Crossref | GoogleScholarGoogle Scholar | 7221556PubMed |
Walters, J. L. H., De Iuliis, G. N., Dun, M. D., Aitken, R. J., McLaughlin, E. A., Nixon, B., and Bromfield, E. G. (2018). Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress. Biol. Reprod. 98, 784–794.
| Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.Crossref | GoogleScholarGoogle Scholar |
Wen, J., Jiang, J., Ding, C., Dai, J., Liu, Y., Xia, Y., Liu, J., and Hu, Z. (2012). Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis. Fertil. Steril. 97, 1331–1337.e4.
| Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis.Crossref | GoogleScholarGoogle Scholar | 22480819PubMed |
Western, P. S. (2018). Epigenomic drugs and the germline: collateral damage in the home of heritability? Mol. Cell. Endocrinol. 468, 121–133.
| Epigenomic drugs and the germline: collateral damage in the home of heritability?Crossref | GoogleScholarGoogle Scholar | 29471014PubMed |
Whittingham, D. G. (1968). Fertilization of mouse eggs in vitro. Nature 220, 592–593.
| Fertilization of mouse eggs in vitro.Crossref | GoogleScholarGoogle Scholar | 5686738PubMed |
Winship, A. L., Stringer, J. M., Liew, S. H., and Hutt, K. J. (2018). The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing. Hum. Reprod. Update , .
| The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing.Crossref | GoogleScholarGoogle Scholar | 29377997PubMed |
Xiao, S., Coppeta, J. R., Rogers, H. B., Isenberg, B. C., Zhu, J., Olalekan, S. A., McKinnon, K. E., Dokic, D., Rashedi, A. S., Haisenleder, D. J., Malpani, S. S., Arnold-Murray, C. A., Chen, K., Jiang, M., Bai, L., Nguyen, C. T., Zhang, J., Laronda, M. M., Hope, T. J., Maniar, K. P., Pavone, M. E., Avram, M. J., Sefton, E. C., Getsios, S., Burdette, J. E., Kim, J. J., Borenstein, J. T., and Woodruff, T. K. (2017). A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Nat. Commun. 8, 14584.
| A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.Crossref | GoogleScholarGoogle Scholar | 28350383PubMed |
