Role of miRNAs in preimplantation embryo development and their potential as embryo selection biomarkers
Masoumeh Esmaeilivand A B , Ali Abedelahi C , Kobra Hamdi D , Laya Farzadi D , Sepide Goharitaban A C , Amir Fattahi
A B D * and Behrooz Niknafs A B C *
+ Author Affiliations
- Author Affiliations
A Immunology Research Center, Tabriz University of Medical Science, Tabriz, Iran.
B Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
C Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
D Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Handling Editor: Ryan Cabot
Reproduction, Fertility and Development 34(8) 589-597 https://doi.org/10.1071/RD21274
Published online: 20 April 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing
Abstract
Context: MicroRNAs (miRNAs) play different roles in oocyte fertilisation, degradation of maternal transcripts, embryo development, and implantation. During in vitro fertilisation (IVF), different miRNAs are released from embryos into the spent culture media (SCM) that can potentially reflect the status of the embryo.
Aims: This study is the assessment of miRNAs, which secreted in SCM during the IVF cycles can be used as noninvasive biomarkers to predict an embryo’s ability to form a blastocyst, implant, and give live birth.
Methods: Systematic literature search was conducted to review all recent studies about miRNAs as potential non-invasive biomarkers for selecting the best embryos in the assisted reproductive technology (ART) cycle.
Key results: Studies have shown that levels of some miRNAs in the SCM have an association with the implantation potential and pregnancy outcome of the embryo.
Conclusions: Embryo-secreted miRNAs can be used as potential non-invasive biomarkers for selecting the best embryos in the ART cycle. Unfortunately, few human studies evaluated the association between ART outcomes and miRNAs in SCM.
Implications: This review can pave the way for further miRNAs transcriptomic studies on human embryo culture media and introducing a specific miRNA profile as a multivariable prediction model for embryo selection in IVF cycles.
Keywords: ART, biomarker, embryo selection, infertility, IVF, miRNAs, pregnancy, transcriptome.
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