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Reproduction, Fertility and Development Reproduction, Fertility and Development Society
Vertebrate reproductive science and technology
REVIEW

Research progress on the effect of Di-(2-ethylhexyl) phthalate (DEHP) on reproductive health at different periods in life

Haiying Wang A , Xinxin Yang A , Jiashuo Li A , Zhipeng Qi A , Bingchen Liu A , Wei Liu A , Bin Xu A , Zhaofa Xu A and Yu Deng https://orcid.org/0000-0003-2292-2957 A B
+ Author Affiliations
- Author Affiliations

A Department of Environmental Health, School of Public Health, China Medical University, Shenyang,110122, Liaoning, People’s Republic of China.

B Corresponding authors. Email: dengyu.cmu@163.com; ydeng@cmu.edu.cn

Reproduction, Fertility and Development 33(7) 441-446 https://doi.org/10.1071/RD20135
Submitted: 31 May 2020  Accepted: 4 March 2021   Published: 4 May 2021

Abstract

Di-(2-ethylhexyl) phthalate (DEHP) is a representative endocrine-disrupting chemical (EDC) that has reproductive, developmental, neurological and immune toxicity in humans and rodents, of which damage to the reproductive system is the most serious. However, exposure to DEHP at different stages of life may produce different symptoms. Studies on this substance are also controversial. This review describes the reproductive effects of DEHP in males and females at different life stages, including infancy, childhood and adulthood.

Graphical Abstract Image

Keywords: di-(2-ethylhexyl) phthalate, reproductive health, endocrine-disrupting chemicals, fetus, childhood, adulthood.


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