In vitro maturation affects chromosome segregation, spindle morphology and acetylation of lysine 16 on histone H4 in horse oocytes
Federica Franciosi A I , Ghylene Goudet B C D E , Irene Tessaro A , Pascal Papillier B C D E , Rozenn Dalbies-Tran B C D E , Fabrice Reigner F , Stefan Deleuze G , Cecile Douet B C D E , Ileana Miclea H , Valentina Lodde A and Alberto M. Luciano A
+ Author Affiliations
- Author Affiliations
A Reproductive and Developmental Biology Laboratory, Department of Health, Animal Science and Food Safety, University of Milan, via Celoria, 10, Milan, 20133, Italy.
B INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, F-37380, France.
C CNRS, UMR7247, Nouzilly, F-37380, France.
D Université François Rabelais, 60 Rue du Plat d’Étain, Tours, F-37000, France.
E IFCE, Nouzilly, F-37380, France.
F INRA, UEPAO, Nouzilly, F-37380, France.
G Université de Liège, Clinique des Animaux de Compagnie et des Équidés, Place du 20 Août 7, Liège, 4000, Belgium.
H University of Agricultural Sciences and Veterinary Medicine, Calea Mănătur 3-5, Cluj-Napoca 400372, Romania.
I Corresponding author. Email: federica.franciosi1@unimi.it
Reproduction, Fertility and Development 29(4) 721-730 https://doi.org/10.1071/RD15350
Submitted: 28 August 2015 Accepted: 12 November 2015 Published: 14 December 2015
Abstract
Implantation failure and genetic developmental disabilities in mammals are caused by errors in chromosome segregation originating mainly in the oocyte during meiosis I. Some conditions, like maternal ageing or in vitro maturation (IVM), increase the incidence of oocyte aneuploidy. Here oocytes from adult mares were used to investigate oocyte maturation in a monovulatory species. Experiments were conducted to compare: (1) the incidence of aneuploidy, (2) the morphology of the spindle, (3) the acetylation of lysine 16 on histone H4 (H4K16) and (4) the relative amount of histone acetyltransferase 1 (HAT1), K(lysine) acetyltransferase 8 (KAT8, also known as MYST1), histone deacetylase 1 (HDAC1) and NAD-dependent protein deacetylase sirtuin 1 (SIRT1) mRNA in metaphase II stage oocytes that were in vitro matured or collected from peri-ovulatory follicles. The frequency of aneuploidy and anomalies in spindle morphology was increased following IVM, along with a decrease in H4K16 acetylation that was in agreement with our previous observations. However, differences in the amount of the transcripts investigated were not detected. These results suggest that the degradation of transcripts encoding for histone deacetylases and acetyltransferases is not involved in the changes of H4K16 acetylation observed following IVM, while translational or post-translational mechanisms might have a role. Our study also suggests that epigenetic instabilities introduced by IVM may affect the oocyte and embryo genetic stability.
Additional keywords: aneuploidy, histone acetyl-transferases, histone deacetylases, meiosis.
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