Steroids affect gene expression, ciliary activity, glucose uptake, progesterone receptor expression and immunoreactive steroidogenic protein expression in equine oviduct explants in vitro
Hilde Nelis A , Bartosz Wojciechowicz B , Anita Franczak B , Bart Leemans A , Katharina D’Herde C , Karen Goossens D , Pieter Cornillie E , Luc Peelman D , Ann Van Soom A and Katrien Smits A F
+ Author Affiliations
- Author Affiliations
A Ghent University, Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Salisburylaan 133, 9820 Merelbeke, Belgium.
B University of Warmia and Mazury, Department of Animal Physiology, Faculty of Biology and Biotechnology, Oczapowskiego St. 1A, 10-719 Olsztyn, Poland.
C Ghent University, Department of Basic Medical Sciences, De Pintelaan 185 4B3, 9000 Ghent, Belgium.
D Ghent University, Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Heidestraat 19, 9820 Merelbeke, Belgium.
E Ghent University, Department of Morphology, Faculty of Veterinary Medicine, Salisburylaan 133, 9820 Merelbeke, Belgium.
F Corresponding author. Email: katrien.smits@ugent.be
Reproduction, Fertility and Development 28(12) 1926-1944 https://doi.org/10.1071/RD15044
Submitted: 31 January 2015 Accepted: 25 May 2015 Published: 18 June 2015
Abstract
The oviduct undergoes dramatic functional and morphological changes throughout the oestrous cycle of the mare. To unravel the effects of steroids on the morphology, functionality and gene expression of the equine oviduct, an in vitro oviduct explant culture system was stimulated with physiological concentrations of progesterone and 17β-oestradiol. Four conditions were compared: unsupplemented preovulatory explants, preovulatory explants that were stimulated with postovulatory hormone concentrations, unsupplemented postovulatory explants and postovulatory explants that were stimulated with preovulatory hormone concentrations. The modulating effects of both steroids on oviduct explants were investigated and the following parameters examined: (1) ciliary activity, (2) glucose consumption and lactate production pattern, (3) ultrastructure, (4) mRNA expression of embryotrophic genes, (5) steroidogenic capacities of oviductal explants and (6) progesterone receptor expression. The present paper shows that the equine oviduct is an organ with potential steroidogenic capacities, which is highly responsive to local changes in progesterone and 17β-oestradiol concentrations at the level of morphology, functionality and gene expression of the oviduct. These data provide a basis to study the importance of endocrine and paracrine signalling during early embryonic development in the horse.
Additional keywords: aromatase, 3-beta-HSD, cytochrome P450scc, mare, StAR, steroidogenesis.
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