Localisation and endocrine control of hyaluronan synthase (HAS) 2, HAS3 and CD44 expression in sheep granulosa cells
R. Chavoshinejad A B , W. F. A. Marei A C , G. M. Hartshorne B and A. A. Fouladi-Nashta A D
+ Author Affiliations
- Author Affiliations
A Reproduction Research Group, Royal Veterinary College, Hawkshead Campus, Hawkshead Lane, Hatfield, AL9 7TA, UK.
B Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK.
C Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
D Corresponding author. Email: afouladi@rvc.ac.uk
Reproduction, Fertility and Development 28(6) 765-775 https://doi.org/10.1071/RD14294
Submitted: 10 August 2014 Accepted: 23 September 2014 Published: 27 November 2014
Abstract
The aim of the present study was to investigate the hormonal regulation of hyaluronan (HA) components in sheep granulosa cells. HA components are present in the reproductive tract and have a range of physical and signalling properties related to reproductive function in several species. First, abattoir-derived ovaries of sheep were used to determine the localisation of HA synthase (HAS) 1–3 and CD44 proteins in antral follicles. Staining for HAS1–3 and CD44 proteins was most intense in the granulosa layer. Accordingly, the expression of HAS2, HAS3 and CD44 mRNA was measured in cultured granulosa cells exposed to 0–50 ng mL–1 of 17β-oestradiol and different combinations of oestradiol, gonadotropins, insulin-like growth factor (IGF)-1 and insulin for 48–96 h (1 ng mL–1 FSH, 10 ng mL–1 insulin, 10 ng mL–1 IGF-1, 40 ng mL–1 E2 and 25 ng mL–1 LH.). mRNA expression was quantified by real-time polymerase chain reaction using a fold induction method. The results revealed that the hormones tested generally stimulated mRNA expression of the genes of interest in cultured granulosa cells. Specifically, oestradiol, when combined with IGF-1, insulin and FSH, stimulated HAS2 mRNA expression. Oestradiol and LH had synergistic effects in increasing HAS3 mRNA expression. In conclusion, we suggest that the hormones studied differentially regulate HAS2, HAS3 and CD44 in ovine granulosa cells in vitro. Further work is needed to address the signalling pathways involved.
Additional keywords: follicle, ovary, ovine.
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