Targeting angiogenesis in the pathological ovary
W. Colin Duncan A B and Junko Nio-Kobayashi A
+ Author Affiliations
- Author Affiliations
A MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
B Corresponding author. Email: w.c.duncan@ed.ac.uk
Reproduction, Fertility and Development 25(2) 362-371 https://doi.org/10.1071/RD12112
Submitted: 6 April 2012 Accepted: 13 July 2012 Published: 27 August 2012
Abstract
The ovary is a key tissue in the study of physiological neo-vascularisation in the adult and its study has highlighted important molecules involved in the regulation of angiogenesis in vivo. These include vascular endothelial growth factor, delta-like ligand 4, thrombospondin-1, prokineticin-1 and prostaglandin E2. Targeting these molecular pathways has therapeutic potential and their manipulation has an increasing preclinical and clinical role in the management of the pathological ovary. Targeting angiogenic pathways has utility in the promotion of ovarian angiogenesis to improve tissue and follicle survival and function as well as the prevention and management of ovarian hyperstimulation syndrome. There is a theoretical possibility that targeting angiogenesis may improve the function of the polycystic ovary and a real role for targeting angiogenesis in ovarian cancer.
Additional keywords: corpus luteum, notch signalling, thrombospondin, VEGF.
References
Abd El Aal, D. E., Mohamed, S. A., Amine, A. F., and Meki, A. R. (2005). Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow. Eur. J. Obstet. Gynecol. Reprod. Biol. 118, 219–224.| Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXkvFagtA%3D%3D&md5=d66dea7ff1e27addd6bbe81a1b835a13CAS | 15653207PubMed |
Abramovich, D., Irusta, G., Parborell, F., and Tesone, M. (2010). Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signalling pathway. Fertil. Steril. 93, 1369–1377.
| Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signalling pathway.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXkslyjt7s%3D&md5=1da00089feace139882707f1a39e6702CAS | 19328472PubMed |
Agrawal, R., Sladkevicius, P., Engmann, L., Conway, G. S., Payne, N. N., Bekis, J., Tan, S. L., Campbell, S., and Jacobs, H. S. (1998). Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries. Hum. Reprod. 13, 651–655.
| Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXivF2jsbs%3D&md5=7a9960976c255716f49cb18afba6b22dCAS | 9572428PubMed |
Alvarez, A. A., Axelrod, J. R., Whitaker, R. S., Isner, P. D., Bentley, R. C., Dodge, R. K., and Rodriguez, G. C. (2001). Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumour angiogenesis and survival in platinum-treated patients. Gynecol. Oncol. 82, 273–278.
| Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumour angiogenesis and survival in platinum-treated patients.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXmsVGjurw%3D&md5=c5044ed231ce466f158e5ed557e672caCAS | 11531279PubMed |
Amin, A. F., Abd el-Aal, D. E., Darwish, A. M., and Meki, A. R. (2003). Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor and insulin-like growth factor-1 in women with polycystic ovary syndrome. Fertil. Steril. 79, 938–941.
| Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor and insulin-like growth factor-1 in women with polycystic ovary syndrome.Crossref | GoogleScholarGoogle Scholar | 12749434PubMed |
Araújo, V. R., Silva, G. M., Duarte, A. B., Magalhães, D. M., Almeida, A. P., Gonçalves, R. F., Bruno, J. B., Silva, T. F., Campello, C. C., Rodrigues, A. P., and Figueiredo, J. R. (2011). Vascular endothelial growth factor-A(165) (VEGF-A(165)) stimulates the in vitro development and oocyte competence of goat preantral follicles. Cell Tissue Res. 346, 273–281.
| Vascular endothelial growth factor-A(165) (VEGF-A(165)) stimulates the in vitro development and oocyte competence of goat preantral follicles.Crossref | GoogleScholarGoogle Scholar | 21987221PubMed |
Armstrong, L. C., and Bornstein, P. (2003). Thrombospondins 1 and 2 function as inhibitors of angiogenesis. Matrix Biol. 22, 63–71.
| Thrombospondins 1 and 2 function as inhibitors of angiogenesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXjtVKgtLw%3D&md5=599ebe4aeeab0bbe264e7e5ae0e27f03CAS | 12714043PubMed |
Badawy, A., and Elnashar, A. (2011). Treatment options for polycystic ovary syndrome. Int. J. Womens Health. 3, 25–35.
| Treatment options for polycystic ovary syndrome.Crossref | GoogleScholarGoogle Scholar | 21339935PubMed |
Balasubramanian, R., Plummer, L., Sidis, Y., Pitteloud, N., Martin, C., Zhou, Q. Y., and Crowley, W. F. (2011). The puzzles of the prokineticin 2 pathway in human reproduction. Mol. Cell. Endocrinol. 346, 44–50.
| The puzzles of the prokineticin 2 pathway in human reproduction.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXht1GgsbfI&md5=7d16cf39f3713a1802abc58977169893CAS | 21664414PubMed |
Busso, C., Fernández-Sánchez, M., García-Velasco, J. A., Landeras, J., Ballesteros, A., Muñoz, E., González, S., Simón, C., Arce, J. C., and Pellicer, A. (2010). The non-ergot-derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomised, double-blind, placebo-controlled trial. Hum. Reprod. 25, 995–1004.
| The non-ergot-derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomised, double-blind, placebo-controlled trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjslejtrk%3D&md5=754f1865733f996415547ff08ec769b7CAS | 20139430PubMed |
Campbell, N. E., Greenaway, J., Henkin, J., Moorehead, R. A., and Petrik, J. (2010). The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer. Neoplasia 12, 275–283.
| 1:CAS:528:DC%2BC3cXjt12htbw%3D&md5=9a787de65b898824037eead7bac663a9CAS | 20234821PubMed |
Chen, L., Zhang, J. J., Rafii, S., and Huang, X. Y. (2009). Suppression of tumour angiogenesis by Galpha(13) haploinsufficiency. J. Biol. Chem. 284, 27 409–27 415.
| Suppression of tumour angiogenesis by Galpha(13) haploinsufficiency.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtFyjs77P&md5=51ce332f7a7d1fa805b43db82d732e3dCAS |
Cristina, C., Díaz-Torga, G., Baldi, A., Góngora, A., Rubinstein, M., Low, M. J., and Becú-Villalobos, D. (2005). Increased pituitary vascular endothelial growth factor-a in dopaminergic D2 receptor knockout female mice. Endocrinology 146, 2952–2962.
| Increased pituitary vascular endothelial growth factor-a in dopaminergic D2 receptor knockout female mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXlslGhsLo%3D&md5=b06feaf5802a32ae59a76181c7aad65dCAS | 15817666PubMed |
Damous, L. L., Silva, S. M., Simões, R. S., Morello, R. J., Carbonel, A. P., Simões, M. J., and Montero, E. F. (2008). Remote ischemic preconditioning on neovascularization and follicle viability on ovary autotransplantation in rats. Transplant. Proc. 40, 861–864.
| Remote ischemic preconditioning on neovascularization and follicle viability on ovary autotransplantation in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXlsFyhsr8%3D&md5=cba0eb62def34efc62571d022b0bb9b7CAS | 18455037PubMed |
Delvigne, A., and Rozenberg, S. (2002). Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Hum. Reprod. Update 8, 559–577.
| Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XptlOis78%3D&md5=1989415e741f8569d83f62303cc26bcdCAS | 12498425PubMed |
Donnez, J., and Dolmans, M. M. (2010). Cryopreservation and transplantation of ovarian tissue. Clin. Obstet. Gynecol. 53, 787–796.
| Cryopreservation and transplantation of ovarian tissue.Crossref | GoogleScholarGoogle Scholar | 21048445PubMed |
Duffy, D. M., and Stouffer, R. L. (2002). Follicular administration of a cyclooxygenase inhibitor can prevent oocyte release without alteration of normal luteal function in rhesus monkeys. Hum. Reprod. 17, 2825–2831.
| Follicular administration of a cyclooxygenase inhibitor can prevent oocyte release without alteration of normal luteal function in rhesus monkeys.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XptFOrtb8%3D&md5=a556b89d70365740ad74e4afc3d05235CAS | 12407033PubMed |
Duncan, W. C. (2000). The human corpus luteum: remodelling during luteolysis and maternal recognition of pregnancy. Rev. Reprod. 5, 12–17.
| The human corpus luteum: remodelling during luteolysis and maternal recognition of pregnancy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXotVyisg%3D%3D&md5=6384df973a81c79df24d37fb9dd507bfCAS | 10711731PubMed |
Duncan, W. C., van den Driesche, S., and Fraser, H. M. (2008). Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum. Endocrinology 149, 3313–3320.
| Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXot1amurY%3D&md5=318d49684e873121f73fabcdc2a38eb7CAS | 18388198PubMed |
Duncan, W. C., Myers, M., Dickinson, R. E., van den Driesche, S., and Fraser, H. M. (2009). Luteal development and luteolysis in the primate corpus luteum. Anim. Reprod. 6, 34–46.
El Behery, M. M., Diab, A. E., Mowafy, H., Ebrahiem, M. A., and Shehata, A. E. (2011). Effect of laparoscopic ovarian drilling on vascular endothelial growth factor and ovarian stromal blood flow using 3-dimensional power Doppler. Int. J. Gynaecol. Obstet. 112, 119–121.
| Effect of laparoscopic ovarian drilling on vascular endothelial growth factor and ovarian stromal blood flow using 3-dimensional power Doppler.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhs1Wmt7nJ&md5=10ba2c9ed72ad37cc69f8066ca3d3d86CAS | 21144516PubMed |
Fauser, B. C., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S., Boivin, J., Petraglia, F., Wijeyeratne, C. N., Norman, R. J., Dunaif, A., Franks, S., Wild, R. A., Dumesic, D., and Barnhart, K. (2012). Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil. Steril. 97, 28–38.
| Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.Crossref | GoogleScholarGoogle Scholar | 22153789PubMed |
Fernandez, H., Morin-Surruca, M., Torre, A., Faivre, E., Deffieux, X., and Gervaise, A. (2011). Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review. Reprod. Biomed. Online 22, 556–568.
| Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review.Crossref | GoogleScholarGoogle Scholar | 21511534PubMed |
Ferrara, N., Frantz, G., LeCouter, J., Dillard-Telm, L., Pham, T., Draksharapu, A., Giordano, T., and Peale, F. (2003). Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries. Am. J. Pathol. 162, 1881–1893.
| Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXkvVyjtro%3D&md5=0e680f5b1693560bd9540f4ecb41c12fCAS | 12759245PubMed |
Franks, S. (2009). Do animal models of polycystic ovary syndrome help to understand its pathogenesis and management? Yes, but their limitations should be recognized. Endocrinology 150, 3983–3985.
| Do animal models of polycystic ovary syndrome help to understand its pathogenesis and management? Yes, but their limitations should be recognized.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtFyrtLjM&md5=801dcf2b73486dedd95508638827d1ecCAS | 19700609PubMed |
Fraser, H. M., and Duncan, W. C. (2005). Vascular morphogenesis in the primate ovary. Angiogenesis 8, 101–116.
| Vascular morphogenesis in the primate ovary.Crossref | GoogleScholarGoogle Scholar | 16240058PubMed |
Fraser, H. M., and Duncan, W. C. (2009). SRB Reproduction, Fertility and Development Award Lecture 2008. Regulation and manipulation of angiogenesis in the ovary and endometrium. Reprod. Fertil. Dev. 21, 377–392.
| SRB Reproduction, Fertility and Development Award Lecture 2008. Regulation and manipulation of angiogenesis in the ovary and endometrium.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXisFemsb0%3D&md5=ac4da5dfdb2c88123c026bbc04de70b0CAS | 19261215PubMed |
Fraser, H. M., Bell, J., Wilson, H., Taylor, P. D., Morgan, K., Anderson, R. A., and Duncan, W. C. (2005). Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum. J. Clin. Endocrinol. Metab. 90, 427–434.
| Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXlvFCjug%3D%3D&md5=56588324c813fe06cb86b05b3bd6061cCAS | 15483093PubMed |
Fraser, H. M., Wilson, H., Wulff, C., Rudge, J. S., and Wiegand, S. J. (2006). Administration of vascular endothelial growth factor Trap during the ‘post-angiogenic’ period of the luteal phase causes rapid functional luteolysis and selective endothelial cell death in the marmoset. Reproduction 132, 589–600.
| Administration of vascular endothelial growth factor Trap during the ‘post-angiogenic’ period of the luteal phase causes rapid functional luteolysis and selective endothelial cell death in the marmoset.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xht1ahs7rM&md5=a37c3ee94aeb006306e2a8cbfa6499c6CAS | 17008470PubMed |
Fraser, H. M., Morris, K. D., Wiegand, S. J., and Wilson, H. (2010). Inhibition of vascular endothelial growth factor during the postovulatory period prevents pregnancy in the marmoset. Contraception 82, 572–578.
| Inhibition of vascular endothelial growth factor during the postovulatory period prevents pregnancy in the marmoset.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsVWqt7bK&md5=1e93b9f66f88c74a6e9ebbaeb9eeff96CAS | 21074022PubMed |
Fraser, H. M., Hastings, J. M., Allan, D., Morris, K. D., Rudge, J. S., and Wiegand, S. J. (2012). Inhibition of delta-like ligand 4 induces luteal hypervascularisation followed by functional and structural luteolysis in the primate ovary. Endocrinology 153, 1972–1983.
| Inhibition of delta-like ligand 4 induces luteal hypervascularisation followed by functional and structural luteolysis in the primate ovary.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlsVSmsbs%3D&md5=98a81525c621c7b2be8549fe599691bbCAS | 22334711PubMed |
Friedman, O., Orvieto, R., Fisch, B., Felz, C., Freud, E., Ben-Haroush, A., and Abir, R. (2012). Possible improvements in human ovarian grafting by various host and graft treatments. Hum. Reprod. 27, 474–482.
| Possible improvements in human ovarian grafting by various host and graft treatments.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtVGhtbo%3D&md5=8c3fdc994160a32f3aac85fc55b73661CAS | 22114111PubMed |
Fujii, E. Y., and Nakayama, M. (2010). The measurements of RAGE, VEGF and AGEs in the plasma and follicular fluid of reproductive women: the influence of aging. Fertil. Steril. 94, 694–700.
| The measurements of RAGE, VEGF and AGEs in the plasma and follicular fluid of reproductive women: the influence of aging.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXpvFantr4%3D&md5=7cb468067d63b6e062b18ab569a6679fCAS | 19376511PubMed |
Gaitskell, K., Martinek, I., Bryant, A., Kehoe, S., Nicum, S., and Morrison, J. (2011). Angiogenesis inhibitors for the treatment of ovarian cancer. Cochrane Database Syst. Rev. 7, CD007930.
Gao, M. Z., Zhao, X. M., Sun, Z. G., Hong, Y., Zhao, L. W., and Zhang, H. Q. (2011). Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation. Fertil. Steril. 95, 673–678.
| Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXpsl2jsQ%3D%3D&md5=f925f2507b1deb23c37fc9b27842e89eCAS | 21067720PubMed |
Garside, S. A., Harlow, C. R., Hillier, S. G., Fraser, H. M., and Thomas, F. H. (2010a). Thrombospondin-1 inhibits angiogenesis and promotes follicular atresia in a novel in vitro angiogenesis assay. Endocrinology 151, 1280–1289.
| Thrombospondin-1 inhibits angiogenesis and promotes follicular atresia in a novel in vitro angiogenesis assay.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjvVKqt7k%3D&md5=c35d49f3bdef8b82a6b7e600e52112b7CAS | 20080874PubMed |
Garside, S. A., Henkin, J., Morris, K. D., Norvell, S. M., Thomas, F. H., and Fraser, H. M. (2010b). A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo. Endocrinology 151, 5905–5915.
| A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXpslSqsA%3D%3D&md5=e36284c4d3b6f0e690c201b57645cf76CAS | 20881256PubMed |
Gaytan, F., Morales, C., Bellido, C., Aguilar, E., and Sanchez-Criado, J. E. (1997). Role of prolactin in the regulation of macrophages and in the proliferative activity of vascular cells in newly formed and regressing rat corpora lutea. Biol. Reprod. 57, 478–486.
| Role of prolactin in the regulation of macrophages and in the proliferative activity of vascular cells in newly formed and regressing rat corpora lutea.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXkslaqsLg%3D&md5=716da809ffc60b13ed2fc2c7b0b93317CAS | 9241066PubMed |
Ginther, O. J., Gastal, E. L., Gastal, M. O., and Beg, M. A. (2005). In vivo effects of pregnancy-associated plasma protein-A, activin-A and vascular endothelial growth factor on other follicular-fluid factors during follicle deviation in mares. Reproduction 129, 489–496.
| In vivo effects of pregnancy-associated plasma protein-A, activin-A and vascular endothelial growth factor on other follicular-fluid factors during follicle deviation in mares.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXjs1ertbo%3D&md5=a208bf95672a2c6f34d1d1e677a8d6caCAS | 15798024PubMed |
Goldhar, A. S., Vonderhaar, B. K., Trott, J. F., and Hovey, R. C. (2005). Prolactin-induced expression of vascular endothelial growth factor via Egr-1. Mol. Cell. Endocrinol. 232, 9–19.
| Prolactin-induced expression of vascular endothelial growth factor via Egr-1.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhvVCrsro%3D&md5=98b6a017b385e01890a818233ea81f5eCAS | 15737464PubMed |
Gómez, R., Simón, C., Remohí, J., and Pellicer, A. (2002). Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade. Endocrinology 143, 4339–4348.
| Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade.Crossref | GoogleScholarGoogle Scholar | 12399430PubMed |
Gómez, R., Gonzalez-Izquierdo, M., Zimmermann, R. C., Novella-Maestre, E., Alonso-Muriel, I., Sanchez-Criado, J., Remohi, J., Simon, C., and Pellicer, A. (2006). Low-dose dopamine agonist administration blocks vascular endothelial growth factor (VEGF)-mediated vascular hyperpermeability without altering VEGF receptor 2-dependent luteal angiogenesis in a rat ovarian hyperstimulation model. Endocrinology 147, 5400–5411.
| Low-dose dopamine agonist administration blocks vascular endothelial growth factor (VEGF)-mediated vascular hyperpermeability without altering VEGF receptor 2-dependent luteal angiogenesis in a rat ovarian hyperstimulation model.Crossref | GoogleScholarGoogle Scholar | 16901966PubMed |
Gómez, R., Ferrero, H., Delgado-Rosas, F., Gaytan, M., Morales, C., Zimmermann, R. C., Simón, C., Gaytan, F., and Pellicer, A. (2011). Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment. J. Clin. Endocrinol. Metab. 96, 2484–2492.
| Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment.Crossref | GoogleScholarGoogle Scholar | 21646367PubMed |
Goodheart, M. J., Ritchie, J. M., Rose, S. L., Fruehauf, J. P., De Young, B. R., and Buller, R. E. (2005). The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer. Clin. Cancer Res. 11, 3733–3742.
| The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXktFyrtLo%3D&md5=1317a86aa57d5849c8df96a650f356ecCAS | 15897570PubMed |
Grosdemouge, I., Bachelot, A., Lucas, A., Baran, N., Kelly, P. A., and Binart, N. (2003). Effects of deletion of the prolactin receptor on ovarian gene expression. Reprod. Biol. Endocrinol. 1, 12.
| Effects of deletion of the prolactin receptor on ovarian gene expression.Crossref | GoogleScholarGoogle Scholar | 12646063PubMed |
Gutman, G., Barak, V., Maslovitz, S., Amit, A., Lessing, J. B., and Geva, E. (2008). Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis. Fertil. Steril. 89, 922–926.
| Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmtFylt78%3D&md5=2626ca391c6ce978a8e0fc0588d431b0CAS | 18343373PubMed |
Hanahan, D. (1997). Signalling vascular morphogenesis and maintenance. Science 277, 48–50.
| Signalling vascular morphogenesis and maintenance.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXksVyhtrk%3D&md5=f87568f53398479b27ea39e55692e03aCAS | 9229772PubMed |
Hazzard, T. M., Molskness, T. A., Chaffin, C. L., and Stouffer, R. L. (1999). Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. Mol. Hum. Reprod. 5, 1115–1121.
| Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXivVelsQ%3D%3D&md5=8cf4de376a7bacbd507568129b39e747CAS | 10587365PubMed |
Hazzard, T. M., Christenson, L. K., and Stouffer, R. L. (2000). Changes in expression of vascular endothelial growth factor and angiopoietin-1 and -2 in the macaque corpus luteum during the menstrual cycle. Mol. Hum. Reprod. 6, 993–998.
| Changes in expression of vascular endothelial growth factor and angiopoietin-1 and -2 in the macaque corpus luteum during the menstrual cycle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXosVejurs%3D&md5=864b5ecc43698c839c4fc1a59138ddecCAS | 11044461PubMed |
Hazzard, T. M., Xu, F., and Stouffer, R. L. (2002). Injection of soluble vascular endothelial growth factor receptor 1 into the preovulatory follicle disrupts ovulation and subsequent luteal function in rhesus monkeys. Biol. Reprod. 67, 1305–1312.
| Injection of soluble vascular endothelial growth factor receptor 1 into the preovulatory follicle disrupts ovulation and subsequent luteal function in rhesus monkeys.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XnsV2rtLs%3D&md5=16d3b9baee617b4787f5cbe5535d81b8CAS | 12297549PubMed |
Hellström, M., Phng, L. K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A. K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M. L., Kalen, M., Gerhardt, H., and Betsholtz, C. (2007). Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445, 776–780.
| Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.Crossref | GoogleScholarGoogle Scholar | 17259973PubMed |
Henkin, J., and Volpert, O. V. (2011). Therapies using anti-angiogenic peptide mimetics of thrombospondin-1. Expert Opin. Ther. Targets 15, 1369–1386.
| Therapies using anti-angiogenic peptide mimetics of thrombospondin-1.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1elsbbE&md5=9d183601deda60418ecf419cfce7250bCAS | 22136063PubMed |
Hu, W., Lu, C., Dong, H. H., Huang, J., Shen, D. Y., Stone, R. L., Nick, A. M., Shahzad, M. M., Mora, E., Jennings, N. B., Lee, S. J., Roh, J. W., Matsuo, K., Nishimura, M., Goodman, B. W., Jaffe, R. B., Langley, R. R., Deavers, M. T., Lopez-Berestein, G., Coleman, R. L., and Sood, A. K. (2011). Biological roles of the Delta family Notch ligand Dll4 in tumour and endothelial cells in ovarian cancer. Cancer Res. 71, 6030–6039.
| Biological roles of the Delta family Notch ligand Dll4 in tumour and endothelial cells in ovarian cancer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtFKntb3I&md5=6106a570916801683aebd0aea9fa67c9CAS | 21795478PubMed |
Huang, Y., Hua, K., Zhou, X., Jin, H., Chen, X., Lu, X., Yu, Y., Zha, X., and Feng, Y. (2008). Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma. Cell Res. 18, 780–791.
| Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXnvFyhsb8%3D&md5=0cdfd793666e755ddedb0e579cb50903CAS | 18574502PubMed |
Lawler, J. (2002). Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumour growth. J. Cell. Mol. Med. 6, 1–12.
| Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumour growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XksVCjt74%3D&md5=a4e1bb61ec51b5f320d469669a6c4813CAS | 12003665PubMed |
Levit, A., Yarnitzky, T., Wiener, A., Meidan, R., and Niv, M. Y. (2011). Modelling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs. PLoS ONE 6, e27990.
| Modelling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1WjtbvP&md5=d6deacb3e3b6fdf130db0fe7c1ec2b93CAS | 22132188PubMed |
Li, W., Ji, Z. L., Zhuo, G. C., Xu, R. J., Wang, J., and Jiang, H. R. (2010). Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice. Med. Oncol. 27, 98–104.
| Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice.Crossref | GoogleScholarGoogle Scholar | 19235530PubMed |
Li, W., Wang, J., Jiang, H. R., Xu, X. L., Zhang, J., Liu, M. L., and Zhai, L. Y. (2011). Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo. Int. J. Mol. Sci. 12, 668–681.
| Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1Gmtb0%3D&md5=be47f8ebdfee2926ab3a90a0c8a5518aCAS | 21340007PubMed |
Lobov, I. B., Renard, R. A., Papadopoulos, N., Gale, N. W., Thurston, G., Yancopoulos, G. D., and Wiegand, S. J. (2007). Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl. Acad. Sci. USA 104, 3219–3224.
| Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjtVCntr8%3D&md5=47b3d0e23caa9562a4cc8164f951bf1cCAS | 17296940PubMed |
Malaguarnera, L., Imbesi, R. M., Scuto, A., D’Amico, F., Licata, F., Messina, A., and Sanfilippo, S. (2004). Prolactin increases HO-1 expression and induces VEGF production in human macrophages. J. Cell. Biochem. 93, 197–206.
| Prolactin increases HO-1 expression and induces VEGF production in human macrophages.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXns1Siu7w%3D&md5=48470cea5f1daf80a01e76990d7ea531CAS | 15352176PubMed |
Maldonado-Pérez, D., Evans, J., Denison, F., Millar, R. P., and Jabbour, H. N. (2007). Potential roles of the prokineticins in reproduction. Trends Endocrinol. Metab. 18, 66–72.
| Potential roles of the prokineticins in reproduction.Crossref | GoogleScholarGoogle Scholar | 17208447PubMed |
Martelli, A., Bernabò, N., Berardinelli, P., Russo, V., Rinaldi, C., Di Giacinto, O., Mauro, A., and Barboni, B. (2009). Vascular supply as a discriminating factor for pig preantral follicle selection. Reproduction 137, 45–58.
| Vascular supply as a discriminating factor for pig preantral follicle selection.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXovVKgsLo%3D&md5=bba096043cd9ba1486a4725ac6b5e5f0CAS | 18840644PubMed |
Mathur, R., Kailasam, C., and Jenkins, J. (2007). Review of the evidence base of strategies to prevent ovarian hyperstimulation syndrome. Hum. Fertil. 10, 75–85.
| Review of the evidence base of strategies to prevent ovarian hyperstimulation syndrome.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmtlGrsLw%3D&md5=fbe6f2e5428f3b67695776d658ec93afCAS |
McFee, R. M., Rozell, T. G., and Cupp, A. S. (2012). The balance of pro-angiogenic and anti-angiogenic VEGFA isoforms regulate follicle development. Cell Tissue Res. , .
| The balance of pro-angiogenic and anti-angiogenic VEGFA isoforms regulate follicle development.Crossref | GoogleScholarGoogle Scholar | 22322423PubMed |
Monnier, J., and Samson, M. (2010). Prokineticins in angiogenesis and cancer. Cancer Lett. 296, 144–149.
| Prokineticins in angiogenesis and cancer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXpsFOqtbY%3D&md5=c495a6b96d8234366c9ca4292fc323d8CAS | 20633984PubMed |
Monteleone, P., Giovanni Artini, P., Simi, G., Casarosa, E., Cela, V., and Genazzani, A. R. (2008). Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF. J. Assist. Reprod. Genet. 25, 183–186.
| Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF.Crossref | GoogleScholarGoogle Scholar | 18449636PubMed |
Oberaigner, W., Minicozzi, P., Bielska-Lasota, M., Allemani, C., de Angelis, R., Mangone, L., and Sant, M. (2012). Survival for ovarian cancer in europe: the across-country variation did not shrink in the past decade. Acta Oncol. , .
| Survival for ovarian cancer in europe: the across-country variation did not shrink in the past decade.Crossref | GoogleScholarGoogle Scholar | 22313338PubMed |
Obermajer, N., Muthuswamy, R., Odunsi, K., Edwards, R. P., and Kalinski, P. (2011). PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. Cancer Res. 71, 7463–7470.
| PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1agtrrM&md5=78f01486e5ec7abbf841dabf06849653CAS | 22025564PubMed |
Palomba, S., Falbo, A., Zullo, F., and Orio, F., (2009). Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr. Rev. 30, 1–50.
| Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjt1eru7g%3D&md5=a50c175b9213bf26b4b9d7fd7b9f4f4aCAS | 19056992PubMed |
Palomba, S., Falbo, A., Carrillo, L., Villani, M. T., Orio, F., Russo, T., Di Cello, A., Cappiello, F., Capasso, S., Tolino, A., Colao, A., Mastrantonio, P., La Sala, G. B., Zullo, F., Cittadini, E.; , METformin in High Responder Italian Group (2011). Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotrophin-stimulated in vitro fertilisation cycles: a randomised, controlled trial. Fertil. Steril. 96, 1384–1390.
| Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotrophin-stimulated in vitro fertilisation cycles: a randomised, controlled trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFygu7zF&md5=9d560abf010c2782572ca7eacdec0d81CAS | 21982727PubMed |
Peitsidis, P., and Agrawal, R. (2010). Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review. Reprod. Biomed. Online 20, 444–452.
| Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtFWmtrbE&md5=e8c34d286616e5330c3896b64ca72f4aCAS | 20156703PubMed |
Pezzuto, A., Ferrari, B., Coppola, F., and Nardelli, G. B. (2010). LH supplementation in down-regulated women undergoing assisted reproduction with baseline low serum LH levels. Gynecol. Endocrinol. 26, 118–124.
| LH supplementation in down-regulated women undergoing assisted reproduction with baseline low serum LH levels.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXlvFeluw%3D%3D&md5=7554b5c397f7c04099c03c6f30d3ccfbCAS | 19718561PubMed |
Pietrowski, D., Szabo, L., Sator, M., Just, A., and Egarter, C. (2012). Ovarian hyperstimulation syndrome is correlated with a reduction of soluble VEGF receptor protein level and a higher amount of VEGF-A. Hum. Reprod. 27, 196–199.
| Ovarian hyperstimulation syndrome is correlated with a reduction of soluble VEGF receptor protein level and a higher amount of VEGF-A.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1CqtrzL&md5=2404b9b066801b1ab984794b4fa0cb87CAS | 22016416PubMed |
Qiu, Y., Seager, M., Osman, A., Castle-Miller, J. S., Bevan, H. S., Tortonese, D. J., Murphy, D., Harper, S. J., Fraser, H. M., Donaldson, L. F., and Bates, D. O. (2012). Ovarian VEGF165b expression regulates follicular development, corpus luteum function and fertility. Reproduction , .
| Ovarian VEGF165b expression regulates follicular development, corpus luteum function and fertility.Crossref | GoogleScholarGoogle Scholar | 22232745PubMed |
Quintana, R., Kopcow, L., Marconi, G., Young, E., Yovanovich, C., and Paz, D. A. (2008). Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model. Fertil. Steril. 90, 1511–1516.
| Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtlSru7zO&md5=6967f7f4ab29ef0f133ad9bb4cf18997CAS | 18166186PubMed |
Rizk, B. (2009). Symposium: update on prediction and management of OHSS. Genetics of ovarian hyperstimulation syndrome. Reprod. Biomed. Online 19, 14–27.
| Symposium: update on prediction and management of OHSS. Genetics of ovarian hyperstimulation syndrome.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtVyhtrzE&md5=98cd4cb7e69b3f25d7b7241250f34a5aCAS | 19573286PubMed |
Rodewald, M., Herr, D., Fraser, H. M., Hack, G., Kreienberg, R., and Wulff, C. (2007). Regulation of tight-junction proteins occludin and claudin 5 in the primate ovary during the ovulatory cycle and after inhibition of vascular endothelial growth factor. Mol. Hum. Reprod. 13, 781–789.
| Regulation of tight-junction proteins occludin and claudin 5 in the primate ovary during the ovulatory cycle and after inhibition of vascular endothelial growth factor.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtlaqtrzF&md5=48c32bf27197e12ada38c516a50c32f4CAS | 18006538PubMed |
Rodewald, M., Herr, D., Duncan, W. C., Fraser, H. M., Hack, G., Konrad, R., Gagsteiger, F., Kreienberg, R., and Wulff, C. (2009). Molecular mechanisms of ovarian hyperstimulation syndrome: paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability. Hum. Reprod. 24, 1191–1199.
| Molecular mechanisms of ovarian hyperstimulation syndrome: paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXksFejt7Y%3D&md5=07db69bd5fc5584cb0c7b95006ece1c3CAS | 19168871PubMed |
Rogosin, S., and Sandler, A. B. (2012). Beyond Bevacizumab: anti-angiogenic agents. Clin. Lung Cancer , .
| Beyond Bevacizumab: anti-angiogenic agents.Crossref | GoogleScholarGoogle Scholar | 22297207PubMed |
Rubatt, J. M., Darcy, K. M., Hutson, A., Bean, S. M., Havrilesky, L. J., Grace, L. A., Berchuck, A., and Secord, A. A. (2009). Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status and angiogenic marker expression: a Gynecologic Oncology Group study. Gynecol. Oncol. 112, 469–474.
| Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status and angiogenic marker expression: a Gynecologic Oncology Group study.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXisVOiurc%3D&md5=69d4e36a10b06c30ddf577c601d32cbaCAS | 19135712PubMed |
Sakurai, T., Suzuki, K., Yoshie, M., Hashimoto, K., Tachikawa, E., and Tamura, K. (2011). Stimulation of tube formation mediated through the prostaglandin EP2 receptor in rat luteal endothelial cells. J. Endocrinol. 209, 33–43.
| Stimulation of tube formation mediated through the prostaglandin EP2 receptor in rat luteal endothelial cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXlt1Olsbk%3D&md5=b64917b5d38d37e13be2889172d72567CAS | 21273371PubMed |
Sboros, V., Averkiou, M., Lampaskis, M., Thomas, D. H., Silva, N., Strouthos, C., Docherty, J., and McNeilly, A. S. (2011). Imaging of the ovine corpus luteum microcirculation with contrast ultrasound. Ultrasound Med. Biol. 37, 59–68.
| Imaging of the ovine corpus luteum microcirculation with contrast ultrasound.Crossref | GoogleScholarGoogle Scholar | 21144958PubMed |
Seekallu, S. V., Toosi, B. M., and Rawlings, N. C. (2009). LH pulse frequency and the emergence and growth of ovarian antral follicular waves in the ewe during the luteal phase of the oestrous cycle. Reprod. Biol. Endocrinol. 7, 78.
| LH pulse frequency and the emergence and growth of ovarian antral follicular waves in the ewe during the luteal phase of the oestrous cycle.Crossref | GoogleScholarGoogle Scholar | 19638235PubMed |
Shah, D. K., Menon, K. M., Cabrera, L. M., Vahratian, A., Kavoussi, S. K., and Lebovic, D. I. (2010). Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinised granulosa cells in vitro. Fertil. Steril. 93, 2042–2047.
| Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinised granulosa cells in vitro.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXlsVOitr8%3D&md5=4f83438959e62bc4a0d52ae2a821e7e9CAS | 19342033PubMed |
Shikanov, A., Zhang, Z., Xu, M., Smith, R. M., Rajan, A., Woodruff, T. K., and Shea, L. D. (2011). Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice. Tissue Eng. Part A 17, 3095–3104.
| Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFKnt7jE&md5=83ce744916bfb6b977dd9392ab81c6dbCAS | 21740332PubMed |
Skaznik-Wikiel, M. E., Sharma, R. K., Selesniemi, K., Lee, H. J., Tilly, J. L., and Falcone, T. (2011). Granulocyte colony-stimulating factor in conjunction with vascular endothelial growth factor maintains primordial follicle numbers in transplanted mouse ovaries. Fertil. Steril. 95, 1405–1409.
| Granulocyte colony-stimulating factor in conjunction with vascular endothelial growth factor maintains primordial follicle numbers in transplanted mouse ovaries.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXjs1Cktrc%3D&md5=3fcf039bd046a22cc5c13f6c292262c6CAS | 21269609PubMed |
Stanek, M. B., Borman, S. M., Molskness, T. A., Larson, J. M., Stouffer, R. L., and Patton, P. E. (2007). Insulin and insulin-like growth factor stimulation of vascular endothelial growth factor production by luteinised granulosa cells: comparison between polycystic ovarian syndrome (PCOS) and non-PCOS women. J. Clin. Endocrinol. Metab. 92, 2726–2733.
| Insulin and insulin-like growth factor stimulation of vascular endothelial growth factor production by luteinised granulosa cells: comparison between polycystic ovarian syndrome (PCOS) and non-PCOS women.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXotVyltro%3D&md5=f4ae49ba7a0d280417d00f2ecce1e324CAS | 17488794PubMed |
Stocco, C., Telleria, C., and Gibori, G. (2007). The molecular control of corpus luteum formation, function and regression. Endocr. Rev. 28, 117–149.
| The molecular control of corpus luteum formation, function and regression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjtFCgsrc%3D&md5=8e1a123bdd1c6e80e7ec5a5b70f7fcd9CAS | 17077191PubMed |
Suchting, S., Freitas, C., le Noble, F., Benedito, R., Breant, C., Duarte, A., and Eichmann, A. (2007). The Notch ligand-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl. Acad. Sci. USA 104, 3225–3230.
| The Notch ligand-like 4 negatively regulates endothelial tip cell formation and vessel branching.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjtVWlsbg%3D&md5=c93281eed9dc368a2a8dcb72ac59a054CAS | 17296941PubMed |
Sugino, N., Suzuki, T., Sakata, A., Miwa, I., Asada, H., Taketani, T., Yamagata, Y., and Tamura, H. (2005). Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy. J. Clin. Endocrinol. Metab. 90, 6141–6148.
| Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXht1alt7fI&md5=511c6ac9b5f86ade17057bcdb35df64cCAS | 16118339PubMed |
Swanton, A., Lighten, A., Granne, I., McVeigh, E., Lavery, S., Trew, G., Talmor, A., Raine-Fenning, N., Jayaprakasan, K., and Child, T. (2011). Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomised trial. Hum. Reprod. 26, 2178–2184.
| Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomised trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXptFCnsLo%3D&md5=421f5013f435743789a154020d4e4f1aCAS | 21593045PubMed |
Tamasi, G., Casolaro, M., Magnani, A., Sega, A., Chiasserini, L., Messori, L., Gabbiani, C., Valiahdi, S. M., Jakupec, M. A., Keppler, B. K., Hursthouse, M. B., and Cini, R. (2010). New platinum–oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro. J. Inorg. Biochem. 104, 799–814.
| New platinum–oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXntlajt7Y%3D&md5=0961118c8b87b1e69b102fd1a443e325CAS | 20447694PubMed |
Tatone, C., Amicarelli, F., Carbone, M. C., Monteleone, P., Caserta, D., Marci, R., Artini, P. G., Piomboni, P., and Focarelli, R. (2008). Cellular and molecular aspects of ovarian follicle ageing. Hum. Reprod. Update 14, 131–142.
| Cellular and molecular aspects of ovarian follicle ageing.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXisVKmurs%3D&md5=1c8cf444c8e4608eff16172d1d74a37aCAS | 18239135PubMed |
Teoh, D., and Secord, A. A. (2012). Anti-angiogenic agents in combination with chemotherapy for the treatment of epithelial ovarian cancer. Int. J. Gynecol. Cancer 22, 348–359.
| Anti-angiogenic agents in combination with chemotherapy for the treatment of epithelial ovarian cancer.Crossref | GoogleScholarGoogle Scholar | 22266932PubMed |
Thierry van Dessel, H. J., Lee, P. D., Faessen, G., Fauser, B. C., and Giudice, L. C. (1999). Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 84, 3030–3035.
| Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1MvhsFKjsw%3D%3D&md5=ce60eb4b3e58c2cabf7f8e54d76e3bdcCAS | 10487660PubMed |
Thomas, C. M., Boss, E. A., Boonstra, H., van Tienoven, D., Sweep, C. G., and Massuger, L. F. (2008). Gonadotrophins and female sex steroid hormones in cyst fluid and serum from patients with ovarian tumours. Eur. J. Gynaecol. Oncol. 29, 468–472.
| 1:STN:280:DC%2BD1cjotl2lug%3D%3D&md5=000a055f3baf99d7683ad6eaa07abf16CAS | 19051814PubMed |
Tso, L. O., Costello, M. F., Albuquerque, L. E., Andriolo, R. B., and Freitas, V. (2009). Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. Cochrane Database Syst. Rev. 15, CD006105.
Uddin, S., Ahmed, M., Hussain, A., Assad, L., Al-Dayel, F., Bavi, P., Al-Kuraya, K. S., and Munkarah, A. (2010). Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. Int. J. Cancer 126, 382–394.
| Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsFGjsrvE&md5=d31acc507bf3c645661b036a80a1e36cCAS | 19621391PubMed |
van de Lagemaat, R., Raafs, B. C., van Koppen, C., Timmers, C. M., Mulders, S. M., and Hanssen, R. G. (2011). Prevention of the onset of ovarian hyperstimulation syndrome (OHSS) in the rat after ovulation induction with a low molecular weight agonist of the LH receptor compared with hCG and rec-LH. Endocrinology 152, 4350–4357.
| Prevention of the onset of ovarian hyperstimulation syndrome (OHSS) in the rat after ovulation induction with a low molecular weight agonist of the LH receptor compared with hCG and rec-LH.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsVOrtb3O&md5=7c367f5fb139cb5ed7741f31d437465fCAS | 21896671PubMed |
van den Driesche, S., Myers, M., Gay, E., Thong, K. J., and Duncan, W. C. (2008). Human chorionic gonadotrophin up-regulates hypoxia inducible factor-1 alpha in luteinised granulosa cells: implications for the hormonal regulation of vascular endothelial growth factor A in the human corpus luteum. Mol. Hum. Reprod. 14, 455–464.
| Human chorionic gonadotrophin up-regulates hypoxia inducible factor-1 alpha in luteinised granulosa cells: implications for the hormonal regulation of vascular endothelial growth factor A in the human corpus luteum.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtVSjsr7M&md5=3848b4cf81b423252eeadb5474f18600CAS | 18591213PubMed |
Vardhana, P. A., Julius, M. A., Pollak, S. V., Lustbader, E. G., Trousdale, R. K., and Lustbader, J. W. (2009). A unique human chorionic gonadotrophin antagonist suppresses ovarian hyperstimulation syndrome in rats. Endocrinology 150, 3807–3814.
| A unique human chorionic gonadotrophin antagonist suppresses ovarian hyperstimulation syndrome in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXpsV2ru7o%3D&md5=28cc110f9e2d0155fbf511507f0e47a7CAS | 19443574PubMed |
Várnagy, A., Bódis, J., Mánfai, Z., Wilhelm, F., Busznyák, C., and Koppán, M. (2010). Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome. Fertil. Steril. 93, 2281–2284.
| Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome.Crossref | GoogleScholarGoogle Scholar | 19261278PubMed |
Vikhanskaya, F., Bani, M. R., Borsotti, P., Ghilardi, C., Ceruti, R., Ghisleni, G., Marabese, M., Giavazzi, R., Broggini, M., and Taraboletti, G. (2001). p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumour angiogenesis. Oncogene 20, 7293–7300.
| p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumour angiogenesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXovVOntL4%3D&md5=76757f5716cdd670b6ac25fb67d29036CAS | 11704858PubMed |
Vlahos, N. P., Bugg, E. M., Shamblott, M. J., Phelps, J. Y., Gearhart, J. D., and Zacur, H. A. (2001). Prolactin receptor gene expression and immunolocalisation of the prolactin receptor in human luteinised granulosa cells. Mol. Hum. Reprod. 7, 1033–1038.
| Prolactin receptor gene expression and immunolocalisation of the prolactin receptor in human luteinised granulosa cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXovVKjsbo%3D&md5=6a20aced9bc1663fa0827ee47df4a144CAS | 11675469PubMed |
Wulff, C., Wilson, H., Largue, P., Duncan, W. C., Armstrong, D. G., and Fraser, H. M. (2000). Angiogenesis in the human corpus luteum: localisation and changes in angiopoietins, tie-2 and vascular endothelial growth factor messenger ribonucleic acid. J. Clin. Endocrinol. Metab. 85, 4302–4309.
| Angiogenesis in the human corpus luteum: localisation and changes in angiopoietins, tie-2 and vascular endothelial growth factor messenger ribonucleic acid.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXotlWms70%3D&md5=df1bc28438c6eb86028bed57ef222328CAS | 11095472PubMed |
Wulff, C., Wilson, H., Wiegand, S. J., Rudge, J. S., and Fraser, H. M. (2002). Prevention of thecal angiogenesis, antral follicular growth and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2. Endocrinology 143, 2797–2807.
| Prevention of thecal angiogenesis, antral follicular growth and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XltVymtL8%3D&md5=9ed60f3c2ed3adddc26e0a878dac3597CAS | 12072415PubMed |
Xin, B., Yokoyama, Y., Shigeto, T., Futagami, M., and Mizunuma, H. (2007b). Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers. Cancer 110, 791–800.
| Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtVajsrbK&md5=682a9145aeda2a3aedec40baf6803759CAS | 17582802PubMed |
Xin, B., Yokoyama, Y., Shigeto, T., and Mizunuma, H. (2007a). Anti-tumour effect of non-steroidal anti-inflammatory drugs on human ovarian cancers. Pathol. Oncol. Res. 13, 365–369.
| Anti-tumour effect of non-steroidal anti-inflammatory drugs on human ovarian cancers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjs1Chu7k%3D&md5=8edef4394442401f3aa190ad5b05fe5dCAS | 18158574PubMed |
Xu, F., and Stouffer, R. L. (2005). Local delivery of angiopoietin-2 into the preovulatory follicle terminates the menstrual cycle in rhesus monkeys. Biol. Reprod. 72, 1352–1358.
| Local delivery of angiopoietin-2 into the preovulatory follicle terminates the menstrual cycle in rhesus monkeys.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXksFGqsLk%3D&md5=8f478b4ba348177a0cd6150f850c59a7CAS | 15703373PubMed |
Yan, M., and Plowman, G. D. (2007). Delta-like 4/Notch signalling and its therapeutic implications. Clin. Cancer Res. 13, 7243–7246.
| Delta-like 4/Notch signalling and its therapeutic implications.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhsVCktr%2FI&md5=d7facf67e7b7ec2a5a0f2000066d46b2CAS | 18094402PubMed |
Youssef, M. A., van Wely, M., Hassan, M. A., Al-Inany, H. G., Mochtar, M., Khattab, S., and van der Veen, F. (2010). Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis. Hum. Reprod. Update 16, 459–466.
| Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVektr7I&md5=9dfadadefedfa6cbd6d143e3eac515c7CAS | 20354100PubMed |
Zhang, L., Yang, N., Conejo-Garcia, J. R., Katsaros, D., Mohamed-Hadley, A., Fracchioli, S., Schlienger, K., Toll, A., Levine, B., Rubin, S. C., and Coukos, G. (2003). Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma. Clin. Cancer Res. 9, 264–272.
| 12538479PubMed |
