Caloric restriction, but not caloric loading, affects circulating fetal and maternal C-type natriuretic peptide concentrations in late ovine gestation
B. A. McNeill A C , G. K. Barrell A , M. J. Ridgway A , M. P. Wellby A , T. C. R. Prickett B and E. A. Espiner B
+ Author Affiliations
- Author Affiliations
A Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, Christchurch, New Zealand.
B Department of Medicine, University of Otago, PO Box 4345, Christchurch 8140, New Zealand.
C Corresponding author. Email: bryonymcneill@gmail.com
Reproduction, Fertility and Development 24(8) 1063-1070 https://doi.org/10.1071/RD11312
Submitted: 15 December 2011 Accepted: 25 February 2012 Published: 10 April 2012
Abstract
The factors regulating the greatly elevated concentrations of maternal plasma C-type natriuretic peptide (CNP) forms in ruminant pregnancy are largely unknown, but nutrient status is likely to be important. Previous work has shown that increases in maternal plasma CNP, sourced from the placenta, occur in response to caloric restriction in late gestation. Whether oversupply of nutrients also regulates CNP secretion in pregnancy has not been studied. Hypothesising that CNP in fetal and maternal tissues will be responsive to both deficiency and excess, we studied changes in CNP and a cosecreted fragment, namely N-terminal pro-CNP (NTproCNP), during short-term periods of caloric restriction (CR) and loading (CL). Twin-bearing ewes received CR (fasted Days 121–124), CL (Days 110–124) or control maintenance diets. During CR, fetal plasma CNP forms, insulin-like growth factor (IGF)-1 and liveweight all fell, and maternal plasma NTproCNP increased. During CL, fetal IGF-1 increased, whereas CNP forms and liveweight were unchanged, as were maternal concentrations of CNP forms. The high abundance of CNP peptides in placental tissues was unaffected by these short-term changes in nutrient supply. We conclude that CNP in the fetal–maternal unit is acutely responsive to undernutrition, but is unaffected by oversupply in late gestation.
Additional keywords: insulin-like growth factor-1, N-terminal pro C-type natriuretic peptide, placenta, sheep.
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