Evidence for cross-talk between the LH receptor and LH during implantation in mice
Virginie Gridelet A E , Marie Tsampalas A , Sarah Berndt B , Marie-Thérèse Hagelstein A , Chantal Charlet-Renard A , Valérie Conrath C , Fabien Ectors C , Fabian Hugé A , Carine Munaut B , Jean-Michel Foidart B D , Vincent Geenen A and Sophie Perrier d’Hauterive A D
+ Author Affiliations
- Author Affiliations
A University of Liege, Center of Immunology, Institute of Pathology, Centre Hospitalier Universitaire B-23, 4000 Liege–Sart Tilman, Belgium.
B University of Liege, Laboratory of Tumor and Development Biology, Institute of Pathology, Centre Hospitalier Universitaire B-23, 4000 Liege–Sart Tilman, Belgium.
C University of Liege, Transgenic Platform, Groupe Interdisciplinaire de Génoprotéomique Appliquée, Centre Hospitalier Universitaire B34, 4000 Liege–Sart Tilman, Belgium.
D University of Liege, Centre for Assisted Medical Procreation, Centre Hospitalier Regional de la Citadelle, 4000 Liege, Belgium.
E Corresponding author. Email: virginie.gridelet@ulg.ac.be
Reproduction, Fertility and Development 25(3) 511-522 https://doi.org/10.1071/RD11241
Submitted: 21 September 2011 Accepted: 9 April 2012 Published: 29 May 2012
Abstract
The present study investigated the first interaction that occurs between the blastocyst and endometrium during implantation. Given the ethical objections to studying implantation in humans, a mouse model was used to study the dialogue between luteinising hormone (LH) and luteinising hormone receptor (LHCGR). Several studies performed on LHCGR-knockout mice have generated controversy regarding the importance of the dialogue between LH and LHCGR during implantation. There has been no demonstration of a bioactive LH-like signal produced by the murine blastocyst. The first aim of the present study was to examine and quantify, using radioimmunoassay, the generation of a bioactive LH signal by the murine blastocyst. We went on to examine and quantify endometrial Lhcgr expression to validate the mouse model. Expression of LHCGR in mouse uteri was demonstrated using immunohistochemistry and western blot analysis. To quantify the expression of Lh in the mouse blastocyst and Lhcgr in the endometrium, reverse transcription–polymerase chain reaction (RT-PCR) and real-time quantitative (q) RT-PCR were performed. The results demonstrate that Lhcgr expression in BALB/c mouse endometrial epithelium is increased at the time of implantation and indicate that LHCGR may contribute to the implantation process. In support of this hypothesis, we identified a bioactive LH signal at the time of murine blastocyst implantation.
Additional keywords: embryo signal, endometrium, LHCGR.
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