Perspectives on transgenic livestock in agriculture and biomedicine: an update
Jorge A. Piedrahita A C and Natasha Olby B
+ Author Affiliations
- Author Affiliations
A Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
B Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
C Corresponding author. Email: jorge_piedrahita@ncsu.edu
Reproduction, Fertility and Development 23(1) 56-63 https://doi.org/10.1071/RD10246
Published: 7 December 2010
Abstract
It has been 30 years since the first transgenic mouse was generated and 26 years since the first example of transferring the technology to livestock was published. While there was tremendous optimism in those initial years, with most convinced that genetically modified animals would play a significant role in agricultural production, that has not come to be. So at first sight one could conclude that this technology has, to a large extent, failed. On the contrary, it is believed that it has succeeded beyond our original expectations, and we are now at what is perhaps the most exciting time in the development and implementation of these technologies. The original goals, however, have drastically changed and it is now biomedical applications that are playing a central role in pushing both technical and scientific developments. The combination of advances in somatic cell nuclear transfer, the development of induced pluripotent stem cells and the completion of the sequencing of most livestock genomes ensures a bright and exciting future for this field, not only in livestock but also in companion animal species.
Additional keywords: animal models, bioreactors, somatic cell nuclear transfer, spinal cord repair, xenotransplantation.
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