Adiposity and plane of nutrition influence reproductive neuroendocrine and appetite responses to intracerebroventricular insulin and neuropeptide-Y in sheep
D. W. Miller D E , E. J. Bennett A B , J. L. Harrison A C D , P. A. Findlay A and C. L. Adam A
+ Author Affiliations
- Author Affiliations
A Obesity and Metabolic Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK.
B Sustainable Livestock Systems Group, Scottish Agricultural College, Aberdeen AB21 9YA, UK.
C School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK.
D School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia.
E Corresponding author. Email: d.miller@murdoch.edu.au
Reproduction, Fertility and Development 23(2) 329-338 https://doi.org/10.1071/RD10150
Submitted: 18 June 2010 Accepted: 28 July 2010 Published: 4 January 2011
Abstract
Long-term nutritional background is thought to influence hypothalamic appetite and reproductive neuroendocrine responses to short-term nutritional feedback. In order to investigate this phenomenon, the effects of intracerebroventricular administration of insulin or neuropeptide-Y (NPY) on LH secretion and voluntary food intake (VFI) were examined in sheep that were initially thin and kept on an increasing nutritional plane (INP), or initially fat and kept on a decreasing nutritional plane (DNP), for 10 weeks. Intracerebroventricular insulin stimulated LH secretion and suppressed VFI in INP sheep when initially thin, but not when they became fat, and had no effect on LH in DNP sheep when initially fat, and stimulated LH secretion when they became thin. Intracerebroventricular NPY had no effect on LH or VFI in INP sheep when initially thin, decreased LH secretion and increased VFI when they became fat, and decreased LH secretion in DNP sheep when initially fat but had no effect when they became thin. Therefore, sensitivity to insulin increases with low or decreasing nutritional status and decreases with high or increasing nutritional status, whereas sensitivity to NPY increases with high or increasing nutritional status and decreases with low or decreasing nutritional status. In conclusion, reproductive neuroendocrine and appetite responses to acute changes in nutritional feedback signals depend on the individual’s longer-term nutritional background.
Additional keywords: body fat, food intake, GnRH, hypothalamus, LH.
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