Characterisation of mouse interferon-induced transmembrane protein-1 gene expression in the mouse uterus during the oestrous cycle and pregnancy
Hyun Jung Park A , In Sun Kuk A , Jin Hoi Kim B , Jae Hwan Kim C , Sang Jin Song D , Bum Chae Choi D , Bokyoung Kim E , Nam Hyung Kim F and Hyuk Song A G
+ Author Affiliations
- Author Affiliations
A Department of Animal Science, College of Natural Science, Konkuk University, Chung-ju 380-701, Korea.
B Department of Animal Biotechnology, College of Animal Biotechnology, Konkuk University, Seoul 143-701, Korea.
C CHA Stem Cell Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, Seoul 135-907, Korea.
D Department of Obstetrics and Gynecology, Cration & Love Women’s Hospital, 13-21, Gwangcheon dong, Seo ku, Gwangju 502-210, Korea.
E Department of Physiology, College of Medicine, Konkuk University, Chung-ju 380-701, Korea.
F Department of Animal Science, College of Agriculture, Chungbuk National University, Choung-ju 361-763, Korea.
G Corresponding author. Email: lovelyhusband@kku.ac.kr
Reproduction, Fertility and Development 23(6) 798-808 https://doi.org/10.1071/RD10086
Submitted: 28 April 2010 Accepted: 16 February 2011 Published: 7 July 2011
Abstract
During the oestrous cycle, pregnancy and parturition, the uterus undergoes marked morphological, physiological and functional changes. Amid these changes, the Wnt/β-catenin signalling pathway has been identified as having a crucial role in regulating associated biological events. Recently, based on results from a mouse embryo study, interferon-induced transmembrane protein 1 (Ifitm1) was reported as a downstream molecule of the Wnt/β-catenin signalling pathway. Differential expression patterns of the Ifitm1 gene during the oestrous cycle, pregnancy and parturition were identified in the present study. Quantitative real-time polymerase chain reaction data from uterine samples of mice induced start the oestrous cycle by injection of human chorionic gonadotropin (hCG) and revealed that Ifitm1 mRNA expression increased from late pro-oestrus to metoestrus, and decreased during dioestrus and early pro-oestrus. During pregnancy, Ifitm1 gene expression was minimal until parturition, but increased markedly 2 days after parturition. This significant elevation in Ifitm1 gene expression at post partum stage was identical to Ifitm1 expression after the induction of abortion by injection of prostaglandin F2α. Interestingly, pregnant mare serum gonadotropin (PMSG) and oestrogen are also facilitates changes in Ifitm1 gene expression in an ovariectomised (OVX) mouse model. Expression of Ifitm1 mRNA was higher in response to PMSG than other hormones investigated. These results suggest that Ifitm1 may be involved in uteri physiology, although the mechanisms involved in the regulation of this gene expression and function in the uterus remain unknown. In the present study, differential expression patterns of the Ifitm1 gene were identified in the uteri of mice and the correlation between the patterns of Ifitm1 gene expression and Wnt/β-catenin signalling discussed.
Additional keywords: Ifitm1, ovariectomy, pregnant mare’s serum gonadotropin, Wnt.
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