Prostate expression of endothelins and their receptors in rat growth
Yoshihiro Wada A , Wataru Takahashi A , Jamshid Latifpour B , Robert M. Weiss B , Koichiro Matsumoto C , Kunihiko Matsui D , Gen Yamada E and Takahisa Imamura F G
+ Author Affiliations
- Author Affiliations
A Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
B Section of Urology, Yale University School of Medicine, New Haven, CT 06520, USA.
C Research Institute for Disease of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
D Clinical Educational Center, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
E Center for Animal Resources and Development (CARD), Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
F Department of Molecular Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
G Corresponding author. Email: taka@gpo.kumamoto-u.ac.jp
Reproduction, Fertility and Development 20(7) 750-759 https://doi.org/10.1071/RD08052
Submitted: 15 March 2008 Accepted: 8 June 2008 Published: 1 August 2008
Abstract
Endothelins (ETs) have been shown to have mitogenic effects on prostate cells in vitro. To study a relationship between ETs and prostate growth, we investigated expression of ET-1 and ET-3 and their receptors ETA and ETB in the dorsolateral (DLP) and ventral (VP) prostate lobes of rats aged 3 weeks, 3 months, and 22 months. The weight ratio of each lobe to the body was not different at 3 weeks but increased more in the DLP than in the VP at 3 months; the ratio did not change at 22 months. The density of the major receptor ETA, measured by radio-labelled ET-1 binding to prostate membrane particulates, was highest at 3 weeks in both prostate lobes and decreased thereafter. mRNA expression levels of ETA, ETB, ET-1, and ET-3 in the DLP and ETA in the VP, as assessed by relative multiplex reverse transcription–polymerase chain reaction, were highest at 3 weeks, and no significant change was seen in mRNA expression of ET-converting enzyme-1. The highest expression of ETA and the ligands at 3 weeks, followed by dramatic growth at 3 months in the DLP, suggests a role of ETA-mediated signal transduction in prostate growth of rats and possibly of humans.
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