Genetic modification of somatic cells for producing animal models and for cellular transplantation
Robert B. Norgren
+ Author Affiliations
- Author Affiliations
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 85805 Nebraska Medical Center, Omaha, NE 68198-5805, USA. Email: rnorgren@unmc.edu
Reproduction, Fertility and Development 18(8) 811-815 https://doi.org/10.1071/RD06074
Submitted: 3 June 2006 Accepted: 4 September 2006 Published: 22 November 2006
Abstract
Great progress has been made in two technologies related to biomedical research: (1) manipulating the genomes of cells; and (2) inducing stem cells in culture to differentiate into potentially useful cell types. These technologies can be used to create animal models of human disease and to provide cells for transplantation to ameliorate human disease. Both embryonic stem cells and adult stem cells have been studied for these purposes. Genetically modified somatic cells provide another source of cells for creating animal models and for cellular transplantation.
Extra keywords: dedifferentiation, hypoxanthine guanine phosphoribosyl transferase, Lesch–Nyhan’s disease, non-human primate, stem gene targeting.
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