Moving to the beat: a review of mammalian sperm motility regulation
Regina M. TurnerDepartment of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA. Email: rmturner@mail.vet.upenn.edu
Reproduction, Fertility and Development 18(2) 25-38 https://doi.org/10.1071/RD05120
Submitted: 21 September 2005 Accepted: 21 September 2005 Published: 14 December 2005
Abstract
Because it is generally accepted that a high percentage of poorly motile or immotile sperm will adversely affect male fertility, analysis of sperm motility is a central part of the evaluation of male fertility. In spite of its importance to fertility, poor sperm motility remains only a description of a pathology whose underlying cause is typically poorly understood. The present review is designed to bring the clinician up to date with the most current understanding of the mechanisms that regulate sperm motility and to raise questions about how aberrations in these mechanisms could be the underlying causes of this pathology.
Extra keywords: flagellum, male infertility, molecular genetics.
Acknowledgments
The author thanks the National Institutes of Health (HD01189-03), CONRAD Mellon Foundation (10100710) and the University of Pennsylvania Research Foundation for their support.
Afzelius, B. A. (1976). A human syndrome caused by immotile cilia. Science 193, 317–319.
| PubMed |
Zarsky, H. A. , Cheng, M. , and Van Der Hoorn, F. A. (2003). Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1. Biol. Reprod. 68, 543–552.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
![](../../media/share/OpenURL_Image.gif)