
%0 Journal Article
%A Almeida, PA 
%A Bolton, VN 
%T The relationship between chromosomal abnormality in the human preimplantation embryo and development in vitro
%J Reproduction, Fertility and Development
%D 1996/03/01
%V 8
%N 2
%P 235-241
%K 
%R https://doi.org/10.1071/RD9960235
%U https://www.publish.csiro.au/paper/RD9960235 
%X The relationship between the survival of the human preimplantation embryo in vitro and chromosomal abnormality was investigated by cytogenetic analysis of a total of 250 embryos of varying morphology between the pronucleate stage and the 8-cell stage. The overall incidence of chromosomal abnormality among these embryos was 49%. At the pronucleate stage (n = 46) the incidence was 65.2%, at the 2-4-cell stage (n = 126) it was 54.6%, and at the 5-8-cell stage (n = 78) it was 27.4%. Cleavage-stage embryos with poor morphology (irregular shaped blastomeres with severe extracellular fragmentation) showed a higher incidence of chromosomal abnormality (62%; 54 of 87 analysed) than those with good morphology (22.2%; 26 of 117 analysed). This study demonstrates: (i) that there is progressive loss of chromosomally-abnormal embryos during preimplantation development; and (ii) that there is an association between chromosomal abnormality and embryo morphology. 
