
TY  - JOUR
A1  - Krishna, BR 
A1  - King, RG 
A1  - Gu, W 
A1  - Brennecke, SP 
T1  - Effect of indomethacin on materno-fetal amino acid transfer in the dual-perfused human placental cotyledon
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 1990
VL  - 2
IS  - 5
SP  - 597
EP  - 602
KW  - 
UR  - https://doi.org/10.1071/RD9900597 
N2  - Indomethacin (1, 10 and 100 mumol L-1) was incrementally infused (8 min for each concentration) into the maternal and fetal circulations of dual-perfused human placental lobules, and measurements were made of materno-fetal amino acid transfer (using the non-metabolizable amino acid alpha-aminoisobutyric acid, or AIB) and fetal effluent perfusate prostaglandin (PG) E levels. No significant changes in AIB transfer compared with controls were observed at any of the doses of indomethacin infused. There was, however, a significant dose-dependent reduction compared with controls in PGE in the fetal circulation with the infusion of indomethacin. 
ER  -

