
%0 Journal Article
%A Sirotkin, Alexander V. 
%A Tarko, Adam 
%A Fabova, Zuzana 
%A Mlyncek, Miloš 
%A Kotwica, Jan 
%A Alwasel, Saleh 
%A Harrath, Abdel Halim 
%T <i>Corrigendum to</i>: Direct action of leptin, obestatin and ginkgo on hormone release by luteinised human ovarian granulosa cells
%J Reproduction, Fertility and Development
%D 2022/11/16
%V 34
%N 18
%P 1146-1146
%K 
%R https://doi.org/10.1071/RD22154_CO
%U https://www.publish.csiro.au/paper/RD22154_CO 
%X Context: The role of metabolic hormones, medicinal plants and their interrelationships in the control of human reproductive processes are poorly understood.Aims: To examine how leptin, obestatin and ginkgo (Ginkgo biloba L.) affect human ovarian hormone release.Methods: We analysed the influence of leptin and obestatin alone and in combination with ginkgo extract on cultured human ovarian granulosa cells. The release of progesterone (P), insulin-like growth factor I (IGF-I), oxytocin (OT) and prostaglandin F (PGF) were analysed by enzyme immunoassay and enzyme-linked immunosorbent assay.Key results: Leptin addition promoted the release of all the measured hormones. Obestatin stimulated the release of P, IGF-I and OT and inhibited PGF output. Ginkgo suppressed P, IGF-I and OT and promoted PGF release. Furthermore, ginkgo changed the stimulatory action of leptin on PGF to an inhibitory one.Conclusions: Leptin and obestatin are involved in the control of human ovarian hormone release and ginkgo influences their function.Implications: Leptin and obestatin could be useful as stimulators of human ovarian cell functions. The suppressive influence of ginkgo on ovarian function should lead to the development of ginkgo-containing drugs. 
