
TY  - JOUR
A1  - Chu, Da-Peng 
A1  - Tian, Shi 
A1  - Sun, Da-Guang 
A1  - Hao, Chan-Juan 
A1  - Xia, Hong-Fei 
A1  - Ma, Xu 
T1  - <i>Corrigendum to</i>: Exposure to mono-n-butyl phthalate disrupts the development of preimplantation embryos
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 2014
VL  - 26
IS  - 3
SP  - 491
EP  - 491
KW  - 
UR  - https://doi.org/10.1071/RD12178_CO 
N2  - Dibutyl phthalate (DBP), a widely used phthalate, is known to cause many serious diseases, especially in the reproductive system. However, little is known about the effects of its metabolite, mono-n-butyl phthalate (MBP), on preimplantation embryo development. In the present study, we found that treatment of embryos with 10&#x2013;3M MBP impaired developmental competency, whereas exposure to 10&#x2013;4M MBP delayed the progression of preimplantation embryos to the blastocyst stage. Furthermore, reactive oxygen species (ROS) levels in embryos were significantly increased following treatment with 10&#x2013;3M MBP. In addition, 10&#x2013;3M MBP increased apoptosis via the release of cytochrome c, whereas immunofluorescent analysis revealed that exposure of preimplantation embryos to MBP concentration-dependently (10&#x2013;5, 10&#x2013;4 and 10&#x2013;3M) decreased DNA methylation. Together, the results indicate a possible relationship between MBP exposure and developmental failure in preimplantation embryos. 
ER  -

