
TY  - JOUR
A1  - Hardy, C. M. 
A1  - Have, J. F. M. ten 
A1  - Mobbs, K. J. 
A1  - Hinds, L. A. 
T1  - Assessment of the immunocontraceptive effect of a zona pellucida 3 peptide antigen in wild mice
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 2002
VL  - 14
IS  - 3
SP  - 151
EP  - 155
KW  - fertility control, immunocontraceptive vaccine, ZP3.
UR  - https://doi.org/10.1071/RD01112 
N2  - Immunizing laboratory mice against a short peptide to mouse zona pellucida protein 3 (mZP3; amino acids 328-342) reduces fertility in some strains. This antigen was therefore tested to see if it is suitable for use in an immunocontraceptive vaccine to control wild mice. Mouse zona pellucida protein 3 peptide conjugated to a carrier protein (keyhole limpet hemocyanin) was considerably more immunogenic and effective in reducing fertility in wild mice when compared with inbred BALB/c mice. Fertility of the immunized wild mice was reduced by over 50% compared with controls, whereas BALB/c mice showed no reduction. Variation in the responses between individual animals to mZP3 peptide was observed and infertility correlated to the presence of cross-reacting antibodies to native zona pellucida in wild, but not BALB/c, mice. 
ER  -

