
%0 Journal Article
%A Salamonsen, Lois A. 
%A Nie, Guiying 
%A Dimitriadis, Eva 
%A Robb, Lorraine 
%A Findlay, Jock K. 
%T Genes involved in implantation
%J Reproduction, Fertility and Development
%D 2001/07/04
%V 13
%N 1
%P 41-49
%K calbindin-D9k, interleukin-11, leukemia inhibitory factor, monoclonal non-specific suppressor factor &#946; , splicing factor SC35.
%R https://doi.org/10.1071/RD00046
%U https://www.publish.csiro.au/paper/RD00046 
%X The endometrium is normally a hostile environment for an embryo, except for a short phase in each reproductive cycle known as the &#8216;window of receptivity&#8217;. The precise molecular events involved in this transformation are not well understood. Application of state-of-the-art techniques of the 1990s has identified some of the genes involved, which are reviewed here. Mice with a null mutation in either the gene for leukemia inhibitory factor or the interleukin-11 receptor &#945; chain are infertile, owing in both cases to a failure of embryo implantation. Both of these genes are expressed in the human endometrium with patterns suggesting a role in human fertility. The technique of RNA differential display has been applied to a comparison of the expression of genes at implantation sites v. inter-implantation sites in the mouse uterus on the first day of implantation, and has defined additional genes whose products may be important for this process. Among these are the calcium-binding protein D9K, the monoclonal non-specific suppressor factor &#946; , and the splicing factor SC35. The major challenge is to determine whether manipulation of such genes can increase or decrease endometrial receptivity in humans. 
