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Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability

Dolores Busso A B E , María José Oñate-Alvarado B , Elisa Balboa A , Juan Castro A , Carlos Lizama B , Gabriela Morales A , Susana Vargas C , Steffen Härtel C , Ricardo D. Moreno B and Silvana Zanlungo A D E
+ Author Affiliations
- Author Affiliations

A Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica. Avda. Bernardo O’Higgins 340. 8331150 Santiago, Chile.

B Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica. Avda. Bernardo O’Higgins 340. 8331150 Santiago, Chile.

C Laboratory for Scientific Image Analysis (SCIAN-Lab), Program of Anatomy and Developmental Biology, Instituto de Ciencias Biomédicas ICBM, Faculty of Medicine, Universidad de Chile, Avda. Independencia 1027. 8389100 Santiago, Chile.

D FONDAP “Center for Genome Regulation”, Avenida Blanco Encalada 2085. 8370415 Santiago, Chile.

E Corresponding authors. Emails: dbusso@med.puc.cl; silvana@med.puc.cl

Reproduction, Fertility and Development 26(4) 609-621 https://doi.org/10.1071/RD12059
Submitted: 25 February 2012  Accepted: 3 April 2013   Published: 29 May 2013



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