
TY  - JOUR
A1  - H Beilharz, Traude 
A1  - Preiss, Thomas 
T1  - ?Cradle?to?grave? regulation of mRNA fate
JF  - Microbiology Australia
JO  - Microbiol. Aust.
Y1  - 2007
VL  - 28
IS  - 2
SP  - 85
EP  - 86
KW  - 
UR  - https://doi.org/10.1071/MA07085 
N2  - Microarray studies in Saccharomyces cerevisiae have set the benchmark for genome-wide analyses, available data-sets covering practically every stage of gene expression from DNA-binding by transcription factors to mRNA export, sub-cellular localisation, translation and decay. A theme to emerge from such data has been the prevalence of coordinate gene regulation. Thus, gene modules or ?regulons? are well recognised at the level of gene transcription and the activity of transcription factors provides an obvious molecular explanation for such coordination. More surprising was the organisation of mRNAs into co-regulated ?post-transcriptional operons?. RNA-binding proteins (RBPs), but also ribonucleoprotein (RNP) complexes involving noncoding RNA, have been proposed as the conceptual equivalent of transcription factors at this level. 
ER  -

