Long-term survival outcome following Staphylococcus aureus bacteraemia
Chong W. Ong A D , Jan L. Roberts B and Peter J. Collignon C
+ Author Affiliations
- Author Affiliations
A Department of Infectious Diseases and Microbiology, Royal Hobart Hospital, Hobart, Tas. 7000, Australia.
B Infection Prevention and Control Unit, ACT Health Directorate, Canberra, ACT 2605, Australia.
C Department of Infectious Diseases and Microbiology, The Canberra Hospital, Canberra, ACT 2605, Australia.
D Corresponding author. Email: chong.ong.work@gmail.com
Healthcare Infection 18(3) 102-109 https://doi.org/10.1071/HI12062
Submitted: 23 December 2012 Accepted: 21 February 2013 Published: 30 April 2013
Journal Compilation © Australasian College for Infection Prevention and Control 2013
Abstract
Aims: To describe long-term survival (beyond 200 days) following Staphylococcus aureus bacteraemia (SAB) and to determine if certain patient subgroups had poorer long-term survival outcomes.
Methods: A single-centre, retrospective, cohort study of all SAB cases at The Canberra Hospital, a tertiary referral centre, from January 1998 to December 2007 was performed. Clinical and demographic data were obtained from a pre-existing prospectively collected database. Patients were followed-up for a minimum of 9 months. Subsets within the cohort were analysed for differences in long-term survival. The main outcome measure was death from any cause.
Results: During the 3889-day study observation period, 439 patients had SAB and were followed for a total of 546 360 person-days. The overall median survival was 3169 days. The mortality rates were 9.6%, 17%, 24%, 29% and 32% at 7, 30, 90, 180 and 365 days respectively. A total of 188 (43%) patients died. Of the 188 deaths, 22%, 40%, 55%, 67% and 75% occurred within the first 7, 30, 90, 180 and 365 days respectively after their SAB episode. Initial analysis showed poorer long-term survival in those patients with older age, MRSA, with an unknown focus of infection, and who were not admitted under the Infectious Diseases team. However, on multivariate analysis, the only independent risk factors for poorer survival were older age, unknown focus of infection and not being admitted under the Infectious Diseases team. MRSA, sex, surgical vs non-surgical admitting team and an association with an intravascular device were not associated with poorer long-term survival.
Conclusions: High rates of death continue for many months after patients have an episode of SAB. Short-term follow-up studies (30 days or less) may miss large numbers of SAB-associated deaths. If accurate data on SAB-associated mortality is needed, then follow-up of these patients will be needed for at least 90 days, ideally performed prospectively with a matched control group consisting of hospitalised patients without SAB.
Additional keywords: bacteraemia, Staphylococcus aureus, survival.
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