
TY  - JOUR
A1  - Lanigan, GW 
T1  - Metabolism of pyrrolizidine alkaloids in the ovine rumen. II. Some factors affecting rate of alkaloid breakdown by rumen fluid <I>in vitro</I>
JF  - Australian Journal of Agricultural Research
JO  - Aust. J.  Agric. Res.
Y1  - 1970
VL  - 21
IS  - 4
SP  - 633
EP  - 640
KW  - 
UR  - https://doi.org/10.1071/AR9700633 
N2  - When the pyrrolizidine alkaloids heliotrine and lasiocarpine were incubated in vitro with sheep's rumen contents, a common metabolic product was formed. This compound was also found as an end-product of metabolism in the rumen contents of sheep fed on a ration containing the plant Heliotropium europaeum. Previously described rumen metabolites of the Heliotropium alkaloids were 1-methylenepyrrolizidine derivatives, e.g. l-goreensine. The newly found product represents a further stage of reduction of l-goreensine in which the 1-methylene group has been replaced by a 1-methyl group. This compound has been identified as 7ß-hydroxyla- methyl-8ß-pyrrolizidine, a previously unknown pyrrolizidine derivative. 
ER  -

