
%0 Journal Article
%A Gallagher, CH 
%T Carbon tetrachloride poisoning in sheep: Effect upon the serum E<sub>260</sub> value and plasma volume
%J Australian Journal of Agricultural Research
%D 1962/12/01
%V 13
%N 6
%P 1073-1081
%K 
%R https://doi.org/10.1071/AR9621073
%U https://www.publish.csiro.au/paper/AR9621073 
%X Serum E260 values were determined at intervals in sheep which were given 50 ml carbon tetrachloride (CCl4) by stomach tube into the rumen, and in untreated sheep. After administration of the drug, the mean E260 value fell initially, being minimal at 3 hr. At this time, the circulating plasma volume had increased by one-fifth, and it is considered that this dilution factor largely explained the fall. The group mean for non-fatal cases rose above the pre-administration level at 7 hr, then returned to it by 24 hr. However, in the one sheep that died from CCl4 poisoning, the serum E260 value remained very high until death at 46 hr. In view of the significant variations in serum E260 values between untreated sheep, and the significant random variations in serum E260 values between times of bleeding such sheep, it is concluded that the determination of serum E260 values at isolated times in individual sheep is of no value as a diagnostic criterion of CCl4 poisoning. 
