N-Acyloxy-N-alkoxyamides are direct-acting mutagenic anomeric amides that react with DNA. Mutagenic activities reflect how structural elements impact on this interaction with DNA. Reliable QSARs (quantitative structure–activity relationships) reveal how hydrophobicity, reactivity and steric factors affect mutagenic activity and can discern intercalative ability of polycyclic aromatics, with good predictive ability.

Gal-β-(1→4)-Gal is a ligand for the adhesin UcaD, a fimbrial protein used by the Gram-negative pathogen Proteus mirabilis to infect the urinary tract. This disaccharide was prepared via glycosylation of a d-galactoside acceptor with a d-Gal trichloroacetimidate donor. The use of a thiogalactoside acceptor resulted in aglycone transfer side reactions.

While gas-phase studies suggest that both palladium-mediated extrusion–insertion (ExIn) and condensation reactions operate for the generation of a N-phenyl-benzamide anion from the phenylsulfinate anion, a double desulfinative biaryl homocoupling reaction is favoured in the solution phase.

This work describes the development of a new non‐metal Brønsted acid catalytic method for the synthesis of 2‐aryl‐3‐carboxylate ester furans and 2,3‐diaryl furans from ynone substrates. The method was shown to be efficient under very mild reaction conditions with up to 94% product yields.