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Contents Vol 70(2)

Atomic Force Microscopy Studies of the Interaction of Antimicrobial Peptides with Bacterial Cells

Anna Mularski A and Frances Separovic A B C
+ Author Affiliations
- Author Affiliations

A School of Chemistry, The University of Melbourne, Melbourne, Vic. 3010, Australia.

B Bio21 Institute, The University of Melbourne, Melbourne, Vic. 3010, Australia.

C Corresponding author. Email: fs@unimelb.edu.au




Anna Mularski obtained her B.A./B.Sc. (Hons) in 2008 and a Ph.D. from the School of Chemistry at the University of Melbourne in 2016. Her research interests are the study of the interactions of membrane active peptides with bacteria using atomic force microscopy.


Frances Separovic obtained a B.A. from Macquarie University in 1986 and a Ph.D. in physics from the University of New South Wales in 1992. Following a post-doctoral fellowship at the NIH (Bethesda, USA), Frances joined the School of Chemistry at the University of Melbourne in 1996. Her research is focused on the study of membrane-active peptides and toxins in situ and biological solid-state NMR spectroscopy.

Australian Journal of Chemistry 70(2) 130-137 https://doi.org/10.1071/CH16425
Submitted: 21 July 2016  Accepted: 15 September 2016   Published: 3 October 2016

Abstract

Antimicrobial peptides (AMPs) are promising therapeutic alternatives to conventional antibiotics. Many AMPs are membrane-active but their mode of action in killing bacteria or in inhibiting their growth remains elusive. Recent studies indicate the mechanism of action depends on peptide structure and lipid components of the bacterial cell membrane. Owing to the complexity of working with living cells, most of these studies have been conducted with synthetic membrane systems, which neglect the possible role of bacterial surface structures in these interactions. In recent years, atomic force microscopy has been utilized to study a diverse range of biological systems under non-destructive, physiologically relevant conditions that yield in situ biophysical measurements of living cells. This approach has been applied to the study of AMP interaction with bacterial cells, generating data that describe how the peptides modulate various biophysical behaviours of individual bacteria, including the turgor pressure, cell wall elasticity, bacterial capsule thickness, and organization of bacterial adhesins.


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