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RESEARCH ARTICLE
Contents Vol 69(9)

A Green Approach for the Synthesis of Novel 7,11-Dihydro-6H-chromeno[3,4-e]isoxazolo[5,4-b]pyridin-6-one Derivatives Using Acidic Ionic Liquid [C4mim][HSO4]

Sudesh Kumari A , M. Rajeswari A and Jitender M. Khurana A B
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, University of Delhi, Delhi 110007, India.

B Corresponding author. Email: jmkhurana@chemistry.du.ac.in

Australian Journal of Chemistry 69(9) 1049-1053 https://doi.org/10.1071/CH16014
Submitted: 12 January 2016  Accepted: 16 March 2016   Published: 18 April 2016

Abstract

A multicomponent reaction capable of affording a wide range of novel 7,11-dihydro-6H-chromeno[3,4-e]isoxazolo[5,4-b]pyridin-6-one derivatives via one-pot three-component condensation of 4-hydroxycoumarin, aromatic aldehydes, and 5-amino-3-methylisoxazole in ionic liquid 1-butyl-3-methylimidazolium hydrogen sulfate ([C4mim][HSO4]) is reported. Structures have been confirmed by spectral and X-ray studies. Crystal packing of 4b has also been reported. Green solvent, short reaction time, easy workup, and high yields are the salient features of the present protocol.


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