Crystallography and New Medicines: Examples from Influenza and Cell Death
Peter M. Colman
+ Author Affiliations
- Author Affiliations
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic. 3052, Australia, and the Department of Medical Biology, The University of Melbourne, Melbourne, Vic. 3052, Australia. Email: pcolman@wehi.edu.au
Australian Journal of Chemistry 67(12) 1720-1723 https://doi.org/10.1071/CH14318
Submitted: 20 May 2014 Accepted: 18 June 2014 Published: 5 August 2014
Abstract
Biomolecular crystallography underpins contemporary drug discovery. The author’s experiences in early (influenza) and recent (cancer) examples mark progress in the sophistication of approaches that have enabled a shift from simpler problems, as in enzyme inhibition, to complex problems, as in blocking protein–protein interactions.
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