Construction of the CSIRO Fragment Library
Craig L. Francis A , Peter W. Kenny B , Olan Dolezal B , Simon Saubern A , Megan Kruger A , G. Paul Savage A , Thomas S. Peat B C and John H. Ryan A C
+ Author Affiliations
- Author Affiliations
A CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, Vic. 3168, Australia.
B CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, Vic. 3052, Australia.
C Corresponding authors. Email: tom.peat@csiro.au; jack.ryan@csiro.au
Australian Journal of Chemistry 66(12) 1473-1482 https://doi.org/10.1071/CH13325
Submitted: 25 June 2013 Accepted: 12 September 2013 Published: 17 October 2013
Abstract
A fundamental component of a successful fragment screening program is a productive fragment library, one that delivers hit fragments with potential for pharmaceutical development. A proprietary fragment library was developed by identifying and extracting subsets of CSIRO’s Compound Collection using two complimentary approaches. Over time, the use of surface plasmon resonance as a front-line screening tool has enabled identification and exclusion of problematic compounds and led to a more reliable fragment screening library.
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