Biodegradable PEG Hydrogels Cross-linkedUsing Biotin-Avidin Interactions

Yingkai Liu; Jingquan Liu; Jiangtao Xu; Shengyu Feng; Thomas P. Davis

doi:10.1071/CH10168

RESEARCH ARTICLE

Previous Next Contents Vol 63(10)

Biodegradable PEG Hydrogels Cross-linkedUsing Biotin-Avidin Interactions

Yingkai Liu ^A , Jingquan Liu ^B ^C ^D , Jiangtao Xu ^B , Shengyu Feng ^A ^D and Thomas P. Davis ^B ^D

+ Author Affiliations

- Author Affiliations

^A Key Laboratory of Special Functional Aggregated Materials, Ministry of Educationand School of Chemistry and Chemical Engineering, Shandong University,Jinan 250100, China.

^B Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.

^C School of Chemical Engineering, Chemistry and Environment, Qingdao University, Qingdao 266071, China.

^D Corresponding authors. Email: fsy@sdu.edu.cn; jingquan.liu@unsw.edu.au; t.davis@unsw.edu.au

Australian Journal of Chemistry 63(10) 1413-1417 https://doi.org/10.1071/CH10168
Submitted: 21 April 2010 Accepted: 25 August 2010 Published: 1 October 2010

Abstract

Poly(ethylene glycol) (PEG) hydrogels are water-swellable, non-toxic, non-immunogenic, and biocompatible. In this paper, we describe the generation of biodegradable PEG hydrogels by cross-linking biotinylated PEG oligomers containing intrinsic disulfide bonds via biotin-avidin interactions. The biotinylated PEG oligomers were synthesized by the condensation reaction between PEG and 3,3′-dithiodipropionic acid, followed by the reaction with biotin. This methodology obviates the need for potentially toxic chemical cross-linking agents that are usually used in the common preparation of hydrogels. Therefore it may be particularly useful in biomedical or pharmaceutical applications.

Acknowledgements

T.P.D. thanks the Australian Research Council for the award of a Federation Fellowship. J.L. acknowledges the award of a UNSW Vice Chancellor’s Post-doctoral Research Fellowship.

References

Biodegradable PEG Hydrogels Cross-linkedUsing Biotin-Avidin Interactions

Abstract

Acknowledgements

Subscriber Login