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RESEARCH FRONT
Contents Vol 61(9)

Photochemotherapy: Targeted Activation of Metal Anticancer Complexes

Nicola J. Farrer A and Peter J. Sadler A B
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK.

B Corresponding author. Email: p.j.sadler@warwick.ac.uk

Australian Journal of Chemistry 61(9) 669-674 https://doi.org/10.1071/CH08088
Submitted: 29 February 2008  Accepted: 29 April 2008   Published: 5 September 2008

Abstract

The present article highlights recent findings in the field of photoactivation of anticancer metal complexes. Developments of some photoactivatable Rh-, Pt-, and Fe-based complexes are discussed and their mechanisms of anticancer action are outlined. Features required for the successful design of photoactive drugs are considered, in particular methods for improving the targeting and selectivity of such complexes through techniques such as conjugate delivery and multiphoton absorption.


References


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