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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Coatings based on dopamine-modified hyaluronic acid and Pluronic F127 for tracheal intubation

Chenggang Wu https://orcid.org/0009-0008-0103-0873 A , Xiyi Yang B , Xiaofeng Tang A and Shuping Zhang https://orcid.org/0000-0002-2891-2613 A *
+ Author Affiliations
- Author Affiliations

A School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093, PR China.

B Department of Invasive Technology, Shanghai Xuhui Central Hospital, Shanghai, 200030, PR China.

* Correspondence to: zhang_lucy9999@vip.126.com

Handling Editor: Richard Hoogenboom

Australian Journal of Chemistry 77, CH23218 https://doi.org/10.1071/CH23218
Submitted: 2 December 2023  Accepted: 19 March 2024  Published online: 17 April 2024

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing.

Abstract

Endotracheal intubation holds significant importance in trauma point care and emergency medicine. However, laryngeal injury and subsequent chronic complications can result from the friction between the mucosa and the tube during intubation. Here we present a lubricant coating based on hyaluronic acid. Inspired by mussels, hyaluronic acid was first conjugated with dopamine to obtain HD, and then a triblock copolymer Pluronic F127 (F127) was complexed with HD to form a micelle layer. Dopamine can assist coating deposition on the tube under weak alkaline conditions, while improving the coating stability. The micelle layer formed by F127 and HD provides excellent water retention and lubrication performance. The friction coefficient of the HD-F127 coating was 56% lower than that of the control, as determined by a friction performance test.

Keywords: dopamine, endotracheal intubation, friction, hyaluronic acid, lubrication, modification, Pluronic F127, polymers.

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