Continuous flow in situ shear stress induced encapsulation of curcumin within spheroidal bovine serum albumin-based nanoparticles
Abeer Yahia H. Alamry A B , Ahmed Hussein Mohammed Al-Antaki A C , Xuan Luo A and Colin L. Raston
A *
A Flinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Adelaide, SA 5042, Australia.
B Department of Chemistry, Faculty of Science, University of Bisha, Bisha 67714, Saudi Arabia.
C Department of Chemistry, Faculty of Science, University of Kufa, Najaf 54001, Iraq.
Australian Journal of Chemistry 75(9) 772-779 https://doi.org/10.1071/CH21345
Submitted: 29 December 2021 Accepted: 11 March 2022 Published: 24 May 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)
Abstract
Nanospheres comprised of bovine serum albumin (BSA) crosslinked with glutaraldehyde possessing different pore sizes are accessible under continuous flow conditions using a vortex fluidic device (VFD) with a rapidly rotating tube tilt angle θ of −45° which overcomes an otherwise build-up of material occurring at θ +45°. The build-up can also be overcome at +45° under continuous flow using ethanol dehydrating conditions at 80°C without the need for crosslinking using glutaraldehyde. As-prepared BSA nanoparticles (BNPs) of ca. 531 nm in diameter were formed at 5k rpm in a single-step process. Similar rapid processing in the presence of curcumin affords composite BNPs@curcumin particles ca. 615 nm in diameter.
Keywords: bovine serum albumin, drug delivery, encapsulation, fluorescence, microfluidics, nanoparticle, vortex fluidic device.
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