Two-Dimensional CoII Coordination Polymer for Photodegradation of Organic Dyes and Treatment of Temporary Osteoporosis of the Hip (TOH) by Regulating wnt/β-catenin/PPARγ Pathway
Hui Chen A B and Xue-Jian Wu A CA Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
B Department of Orthopaedic Surgery, People’s Hospital of Puyang City, Puyang, Henan 457000, China.
C Corresponding author. Email: xuejian_wu1972@126.com
Australian Journal of Chemistry 73(1) 9-15 https://doi.org/10.1071/CH19420
Submitted: 7 September 2019 Accepted: 23 October 2019 Published: 5 December 2019
Abstract
In this study, a new two-dimensional CoII-containing coordination polymer [Co(pda)(H2O)](DMF)2 (1, DMF = N,N-dimethylformamide) based on a light-harvesting triphenylamine type organic ligand has been successfully prepared by reaction of Co(NO3)2⋯6H2O and 4,4′-(phenylazanediyl)dibenzoic acid (H2pda) in a mixed solvent of water and DMF. Complex 1 has significant photocatalytic activity under visible light for the degradation of organic dyes such as rhodamine B (RhB), methylene blue (MB), as well as methyl orange (MO) assisted by H2O2. Compound 1 was investigated for anti-osteoporosis activity, the Annexin V-FITC/PI method was used to test the relationship between apoptosis and osteoporosis and the effect of 1 on bone marrow stem cell (BMSC) apoptosis. The expression levels of wnt/β, catenin, and PPARγ after treatment with 1 was determined by reverse transcription quantitative polymerase chain reaction. The DNA cleavage ability of 1 was further studied by molecular docking.
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