Cubane: A New NMR Internal Standard

Benjamin A. Chalmers; Annette P.-J. Chen; G. Paul Savage; Craig M. Williams

doi:10.1071/CH10107

RESEARCH ARTICLE

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Cubane: A New NMR Internal Standard

Benjamin A. Chalmers ^A , Annette P.-J. Chen ^A , G. Paul Savage ^B and Craig M. Williams ^A ^C

+ Author Affiliations

- Author Affiliations

^A School of Chemistry and Molecular Biosciences, University of Queenland, Brisbane, 4072, Queensland, Australia.

^B CSIRO Molecular and Health and Technologies, Clayton South, 3169, Victoria, Australia.

^C Corresponding author. Email: c.williams3@uq.edu.au

Australian Journal of Chemistry 63(7) 1108-1110 https://doi.org/10.1071/CH10107
Submitted: 4 March 2010 Accepted: 7 May 2010 Published: 15 July 2010

Abstract

Cubane can be considered the ideal internal standard for reactions observed by NMR, due to an almost complete benign reactivity and uniquely reliable ¹H and ¹³C NMR resonances, in wide variety of deuterated solvents.

Acknowledgements

We thank the University of Queensland and the Commonwealth Scientific and Industrial Research Organisation (CSIRO) for financial support and providing dimethyl cubane-1,4-dicarboxylate.

References

^† Sigma-Aldrich Co. are currently reviewing the reintroduction of cubane on the basis of its utility as an internal standard. Limited amounts of material will be made available from the author until this time.

Cubane: A New NMR Internal Standard

Abstract

Acknowledgements

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