Synthesis, Structure, and Selective Cytotoxicity of Organometallic Cp*RuII O-Alkyl-N-phenylcarbamate Sandwich Complexes

Bradley T. Loughrey; Michael L. Williams; Thomas J. Carruthers; Peter G. Parsons; Peter C. Healy

doi:10.1071/CH09420

RESEARCH ARTICLE

Synthesis, Structure, and Selective Cytotoxicity of Organometallic Cp*Ru^II O-Alkyl-N-phenylcarbamate Sandwich Complexes

Bradley T. Loughrey ^A , Michael L. Williams ^A , Thomas J. Carruthers ^A , Peter G. Parsons ^B and Peter C. Healy ^A ^C

+ Author Affiliations

- Author Affiliations

^A Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Qld 4111, Australia.

^B Drug Discovery Group, Queensland Institute of Medical Research, Brisbane, Qld 4029, Australia.

^C Corresponding author. Email: p.healy@griffith.edu.au

Australian Journal of Chemistry 63(2) 245-251 https://doi.org/10.1071/CH09420
Submitted: 31 July 2009 Accepted: 4 November 2009 Published: 26 February 2010

Abstract

Tetraphenylborate salts of the η⁶-arene Cp*Ru^II O-alkyl-N-phenyl carbamate organometallic sandwich complexes, [Cp*Ru(PhNHCO₂R)]BPh₄ for R = Me (1), Et (2), and n-Pr (3), have been prepared by a facile one-pot reaction between ruthenium trichloride, pentamethylcyclopentadiene, and phenylisocyanate in refluxing alcohol solutions, and have been characterized by Fourier-transform IR and NMR spectroscopy, electrospray mass spectrometry, and single-crystal X-ray structure determinations. In vitro cytotoxicity studies show the complexes to be potent growth inhibitors for a range of tumour cell lines, while expressing significantly lower levels of toxicity towards a normal human fibroblast cell line.

Acknowledgements

We thank Griffith University, the Queensland University of Technology and the Eskitis Institute for Cell and Molecular Therapies for support of this work.

References

Synthesis, Structure, and Selective Cytotoxicity of Organometallic Cp*RuII O-Alkyl-N-phenylcarbamate Sandwich Complexes

Abstract

Acknowledgements

Subscriber Login

Synthesis, Structure, and Selective Cytotoxicity of Organometallic Cp*Ru^II O-Alkyl-N-phenylcarbamate Sandwich Complexes