5-Pyrrolidin-2-yltetrazole-Promoted One-Pot Hantzsch Polyhydroquinoline Synthesis Using NH4HCO3 as Nitrogen Source

Weike Su; Jia Li; Jianjun Li

doi:10.1071/CH08197

RESEARCH ARTICLE

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5-Pyrrolidin-2-yltetrazole-Promoted One-Pot Hantzsch Polyhydroquinoline Synthesis Using NH₄HCO₃ as Nitrogen Source

Weike Su ^A ^B , Jia Li ^A and Jianjun Li ^A

+ Author Affiliations

- Author Affiliations

^A Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

^B Corresponding author. Email: suweike@zjut.edu.cn

Australian Journal of Chemistry 61(11) 860-863 https://doi.org/10.1071/CH08197
Submitted: 9 May 2008 Accepted: 10 September 2008 Published: 5 November 2008

Abstract

A straightforward and green synthesis of polyhydroquinoline derivatives was reported via a four-component coupling reaction of aldehydes, dimedone, active methylene compounds, and ammonium bicarbonate in the presence of 5-pyrrolidin-2-yltetrazole under solvent-free conditions. The method offers several advantages including high yields, an environmental friendly procedure, a short reaction time, and easy isolation of products.

Acknowledgements

We are grateful to the National Natural Science Foundation of China (Nos 20476098, 20806073) and the National Key Technology Reasearch and Development Program (No. 2007 BAI34B00) for financial support.

References

5-Pyrrolidin-2-yltetrazole-Promoted One-Pot Hantzsch Polyhydroquinoline Synthesis Using NH4HCO3 as Nitrogen Source

Abstract

Acknowledgements

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5-Pyrrolidin-2-yltetrazole-Promoted One-Pot Hantzsch Polyhydroquinoline Synthesis Using NH₄HCO₃ as Nitrogen Source