A Simple, Efficient, and Green Procedure for the 1,4-Addition of Thiols to Conjugated Alkenes and Alkynes Catalyzed by Sodium Acetate in Aqueous Medium

Brindaban C. Ranu; Tanmay Mandal

doi:10.1071/CH06455

RESEARCH ARTICLE

Previous Contents Vol 60(3)

A Simple, Efficient, and Green Procedure for the 1,4-Addition of Thiols to Conjugated Alkenes and Alkynes Catalyzed by Sodium Acetate in Aqueous Medium

Brindaban C. Ranu ^A ^B and Tanmay Mandal ^A

+ Author Affiliations

- Author Affiliations

^A Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700 032, India.

^B Corresponding author. Email: ocbcr@iacs.res.in

Australian Journal of Chemistry 60(3) 223-227 https://doi.org/10.1071/CH06455
Submitted: 24 October 2006 Accepted: 28 December 2006 Published: 2 April 2007

Abstract

A benign and inexpensive salt, sodium acetate, efficiently catalyzes 1,4-addition of thiols to a variety of conjugated alkenes such as α,β-unsaturated ketones, aldehydes, carboxylic esters, nitriles, nitro compounds, and chalcones in aqueous THF. The reactions are clean, fast, and high yielding.

Acknowledgments

This investigation has enjoyed the financial support from CSIR, New Delhi under grant no. 01(1936)/04. T.M. is also thankful to CSIR for his fellowship.

References

A Simple, Efficient, and Green Procedure for the 1,4-Addition of Thiols to Conjugated Alkenes and Alkynes Catalyzed by Sodium Acetate in Aqueous Medium

Abstract

Acknowledgments

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