Synthesis, Relaxivity, and T1 Relaxation Enhancement of Binuclear Gadolinium(iii) Complexes Based on DTPA or EDTA and Long-Chain Alkyl Esters of l-Lysine
Kaichao Yu A B , Yousef Hamdan A , Fuxian Wan A , Yinxia Li B , Kaixun Huang A and Jinlan Zhou A CA Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China.
B State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
C Corresponding author. E mail: jlmtt@163.com
Australian Journal of Chemistry 60(3) 218-222 https://doi.org/10.1071/CH06214
Submitted: 20 June 2006 Accepted: 30 November 2006 Published: 2 April 2007
Abstract
Eight novel diamino-ester ligands were synthesized by amidation reaction of long-chain alkyl esters of l-lysine with diethylenetriamine pentaacetic acid monoanhydride or ethylenediamine tetraacetic acid monoanhydride. The corresponding dimeric Gd(iii) complexes were obtained by treating these ligands with GdCl3·6H2O. All ligands and complexes were characterized by 1H NMR, FT-IR, and elemental analysis. The longitudinal relaxation time (T1) was measured, and all relaxivity values (R1) of these dimeric Gd(iii) complexes are higher than that of Magnivest (Gd-DTPA). One of these complexes, possessing the highest relaxivity in the DTPA series, was chosen to test the acute toxicity and T1-weighted imaging. It was found that this dimeric Gd(iii) complex exhibits no acute toxicity, and offers highly enhanced MRI signal and increases intention time in the rat liver tissue compared to Magnivest.
Acknowledgments
This work was supported by the National Natural Science Foundation of China (nos 20672039, 20275011, and 10234070), Chinese Academy of Sciences key program kjcx2-sw-h12-03, and the Foundation of the State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics. We also thank Dr Shangwu Ding (Department of Chemistry, National Sun Yat-Sen University) for his good advice and hard work in the modification of this manuscript.
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