Synthesis of Some 4-Oxothiochromenes and Related Compounds

Andris J. Liepa; Oanh Nguyen; Simon Saubern

doi:10.1071/CH05205

RESEARCH ARTICLE

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Synthesis of Some 4-Oxothiochromenes and Related Compounds

Andris J. Liepa ^A ^B , Oanh Nguyen ^A and Simon Saubern ^A

+ Author Affiliations

- Author Affiliations

^A CSIRO Molecular and Health Technologies, Clayton South VIC 3169, Australia.

^B Corresponding author. Email: andy.liepa@csiro.au

Australian Journal of Chemistry 58(12) 864-869 https://doi.org/10.1071/CH05205
Submitted: 5 August 2005 Accepted: 25 October 2005 Published: 20 December 2005

Abstract

Thiosalicylic acids react with 2-substituted N,N-dialkyl acetamides to give 3-substituted-N,N-dialkyl-2-amino-4-oxothiochromenes 13. N-Alkyl 2-piperidone and analogous caprolactams give derivatives of 1,2,3,4-tetrahydrothiochromeno[2,3-b]pyridin-5-one 16a–16d and 7,8,9,10-tetrahydro-6H-5-thia-6-aza-cyclohepta-[b]naphthalen-11-one 16e, 16f. 2-Mercaptonicotinic acid gave a 1,2,3,4-tetrahydro-9-thia-1,8-diazaanthracen-10-one 16g and a 1,2,3,4-tetrahydro-9-thia-1,8-diazaanthracene-10-thione 16h.

Acknowledgments

Thanks to Mr Tony Wilson for technical assistance, to Dr Gary Fallon for verification of the structure of 16h by X-ray analysis, and to DuPont Agricultural Products (Stine–Haskell, Delaware) for biological screening.

References

Synthesis of Some 4-Oxothiochromenes and Related Compounds

Abstract

Acknowledgments

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