Helical Porous Protein Mimics Self-Assembled from Amphiphilic Dendritic Dipeptides*

Virgil Percec; Andrés Dulcey; Mihai Peterca; Monica Ilies; Yoshiko Miura; Ulrica Edlund; Paul A. Heiney

doi:10.1071/CH05092

RESEARCH ARTICLE

Helical Porous Protein Mimics Self-Assembled from Amphiphilic Dendritic Dipeptides*

Virgil Percec ^A ^C , Andrés Dulcey ^A , Mihai Peterca ^B , Monica Ilies ^A , Yoshiko Miura ^A , Ulrica Edlund ^A and Paul A. Heiney ^B

+ Author Affiliations

- Author Affiliations

^A Roy & Diana Vagelos Laboratories, Department of Chemistry, Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, PA 19104-6323, USA.

^B Department of Physics and Astronomy, Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, PA 19104-6396, USA.

^C Corresponding author. Email: percec@sas.upenn.edu

Australian Journal of Chemistry 58(6) 472-482 https://doi.org/10.1071/CH05092
Submitted: 21 April 2005 Accepted: 1 May 2005 Published: 14 June 2005

Abstract

This manuscript reports the synthesis and the self-assembly of (4-3,4,5-3,5)nG₂-CH₂-Boc-l-Tyr-l-Ala-OMe dendritic dipeptides (n = 12, 16). These dendritic dipeptides self-assemble both in solution and in solid states into helical porous supramolecular columns that mimic porous transmembrane proteins. These supramolecular assemblies provide also a new class of tubular supramolecular polymers.

Financial support by the National Science Foundation (DMR-9996288 and DMR-0102459) and the Office of Naval Research is gratefully acknowledged.

References

^* Part of this research was discussed in a plenary lecture presented by V.P. at the 27th Australasian Polymer Symposium, 28 November–2 December 2004, Adelaide.

Helical Porous Protein Mimics Self-Assembled from Amphiphilic Dendritic Dipeptides*

Abstract

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