Selective Carbonyl Propargylation Mediated by SnCl2/NiCl2-KI in Water

Jun Wang; Xiao-Peng Miao; Gu Yuan

doi:10.1071/CH05091

RESEARCH ARTICLE

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Selective Carbonyl Propargylation Mediated by SnCl₂/NiCl₂-KI in Water

Jun Wang ^A , Xiao-Peng Miao ^A and Gu Yuan ^A ^B

+ Author Affiliations

- Author Affiliations

^A Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing 100871, China.

^B Corresponding author. Email: guyuan@pku.edu.cn

Australian Journal of Chemistry 58(8) 611-614 https://doi.org/10.1071/CH05091
Submitted: 20 April 2005 Accepted: 25 July 2005 Published: 31 August 2005

Abstract

Propargylation of carbonyl compounds to produce homopropargylic alcohols plays a very important role in synthetic organic and pharmaceutical chemistry. A novel method that carbonyl compounds and propargyl halide were mediated by SnCl₂/NiCl₂-KI in water at room temperature was developed by us to successfully synthesize homopropargylic alcohols in good yields. The reactions were carried out in an environmentally friendly solution and under mild conditions.

References

Selective Carbonyl Propargylation Mediated by SnCl2/NiCl2-KI in Water

Abstract

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Selective Carbonyl Propargylation Mediated by SnCl₂/NiCl₂-KI in Water