Small Molecules that Mimic Components of Bioactive Protein Surfaces

David P. Fairlie

doi:10.1071/CH04074

RESEARCH ARTICLE

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Small Molecules that Mimic Components of Bioactive Protein Surfaces

David P. Fairlie ^A

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^A Centre for Drug Design & Development, Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia (e-mail: d.fairlie@imb.uq.edu.au).

Australian Journal of Chemistry 57(9) 855-857 https://doi.org/10.1071/CH04074
Submitted: 16 March 2004 Accepted: 26 June 2004 Published: 1 September 2004

Abstract

Small molecules designed to mimic specific structural components of a protein (peptide strands, sheets, turns, helices, or amino acids) can be expected to display agonist or antagonist biological responses by virtue of interacting with the same receptors that recognize the protein. Here we describe some minimalist approaches to structural mimetics of amino acids and of strand, turn, or helix segments of proteins. The designed molecules show potent and selective inhibition of protease, transferase, and phospholipase enzymes, or antagonism of G-protein coupled or transcriptional receptors, and have potent anti-tumour, anti-inflammatory, or antiviral activity.

Acknowledgements

The ARC and NHMRC provided some support for this work.

References

Small Molecules that Mimic Components of Bioactive Protein Surfaces

Abstract

Acknowledgements

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