
%0 Journal Article
%A Harding, MM 
%A Lehn, JM 
%T Synthesis of Oligobipyridine Strands Bearing Nucleoside and Amino Acid Side Chains
%J Australian Journal of Chemistry
%D 1996/10/01
%V 49
%N 10
%P 1023-1027
%K 
%R https://doi.org/10.1071/CH9961023
%U https://www.publish.csiro.au/paper/CH9961023 
%X The synthesis is reported of derivatives of 6,6'-dimethyl-2,2'-bipyridine in which adenosine, thymidine aid tryptophan substituents are introduced at the 4,4'-positions as amide derivatives. Artificial oligonucleoside strands derived from the corresponding trisbipyridyl  ligand , in which three bipyridyl ligands are separated by methyleneoxy bridges, have been prepared. The solubility of the nucleoside-substituted ligands in organic solvents is poor, but acylation of the ribose or deoxyribose units present in the ligands provides a mechanism whereby organic solubility can be improved. These ligands may be used for the preparation of metallo-exoreceptors , with the potential for recognition of biological targets such as nucleic acids. Preliminary metal ion complexation studies have been carried out. 
