
TY  - JOUR
A1  - Brimble, MA 
A1  - Horner, GM 
A1  - Stevenson, RJ 
T1  - Synthesis of Aromatic Spiroacetals
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1996
VL  - 49
IS  - 2
SP  - 189
EP  - 196
KW  - 
UR  - https://doi.org/10.1071/CH9960189 
N2  - The synthesis of aromatic spiroacetal ring systems related to the papulacandins is reported. ortho-Metalation of diisopropylbenzamide, followed by reaction with the electrophiles &#948;- valerolactone, &#947;- butyrolactone and &#947;-valerolactone, provided the keto alcohol adducts (10),(16) and (21) respectively. Reduction of the ketone followed by treatment with acid afforded phthalides (12),(18) and (23). Finally oxidative cyclization with iodobenzene diacetate provided the spiroacetals (7),(14) and (19). 
ER  -

