
TY  - JOUR
A1  - Allan, RD 
A1  - Apostopoulos, C 
A1  - Hambley, TW 
T1  - The Synthesis and Structure of a Cyclobutane Analog of Glutamic Acid With an Acetic Acid Side Chain
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1995
VL  - 48
IS  - 5
SP  - 919
EP  - 928
KW  - 
UR  - https://doi.org/10.1071/CH9950919 
N2  - A synthetic route involving a hydantoin derivative of bicyclo [3.2.0]hept-2-ene has been investigated for the preparation of neurotransmitter analogues containing an additional acetic acid substituent on the cyclobutane ring of the potent NMDA receptor agonist trans-1-aminocyclobutane-1,3-dicarboxylic acid. X-Ray analysis showed that the major cyclobutane amino acid produced had the 2-acetic acid and 3-carboxylic acid substituents in the trans orientation as a result of epimerization during hydantoin hydrolysis. 
ER  -

