
%0 Journal Article
%A Allan, RD 
%A Apostopoulos, C 
%A Hambley, TW 
%T The Synthesis and Structure of a Cyclobutane Analog of Glutamic Acid With an Acetic Acid Side Chain
%J Australian Journal of Chemistry
%D 1995/05/01
%V 48
%N 5
%P 919-928
%K 
%R https://doi.org/10.1071/CH9950919
%U https://www.publish.csiro.au/paper/CH9950919 
%X A synthetic route involving a hydantoin derivative of bicyclo [3.2.0]hept-2-ene has been investigated for the preparation of neurotransmitter analogues containing an additional acetic acid substituent on the cyclobutane ring of the potent NMDA receptor agonist trans-1-aminocyclobutane-1,3-dicarboxylic acid. X-Ray analysis showed that the major cyclobutane amino acid produced had the 2-acetic acid and 3-carboxylic acid substituents in the trans orientation as a result of epimerization during hydantoin hydrolysis. 
